A popular antidepressant was useless for recovery after a stroke – N + 1


Fluoxetine structure

British scientists have denied the use of the popular fluoxetine antidepressant to restore the functionality of patients after a stroke. During the course of their study, participants who took the drug for a year and a half had no fitness improvements compared to the placebo group. Article published in The hand.

Flucosetine – an antidepressant of the selective serotonin reuptake inhibitor group – is often prescribed to patients undergoing a long rehabilitation cycle to reduce the risk of developing depression and anxiety disorder. It has also been believed that during the rehabilitation of patients after a stroke, fluoxetine can help restore physical fitness by improving the process of neurogenesis and improving neuroplasticity (thanks to better synthesis and the function of serotonin), as well as thanks to stimulating effect of the drug. The clinical efficacy of fluoxetine as a means of restoring functionality has not yet been demonstrated.

The scientists decided to do so under the guidance of Martin Dennis (Martin Dennis) of the University of Edinburgh. As part of the FOCUS project (Fluoxetine or Control Under Supervision), they followed more than half a year to 3,127 patients undergoing rehabilitation after a stroke in British clinics: all participants were over 18 years old, were enrolled in a 2-15 study days after a stroke and they had neurological violations. Half of the participants took 20 milligrams of fluoxetine per day and half took a placebo.

For the same patients and the staff of the clinics, the study was completely blind: only the researchers knew in which group a particular participant was. The functionality of the participants at the beginning and at the end of the study was assessed on a Rankin scale: it is usually used to evaluate the effectiveness of rehabilitation.

The scientists found no significant differences (p = 0.439) on the Rankin scale between the control group and the experimental group. This means that fluoxetine did not help improve the function of the limbs of patients. However, the researchers noted that depression was less common in the active group, but there were also 1.41 percent more fractures in the active group.

The authors concluded that the uselessness of fluoxetine to improve the functionality of patients after a stroke. Despite the fact that the drug was able to improve their mental state, medical personnel must also take into account the adverse effects of the drug (in this case, the fractures of the limbs).

The neurocomputer interfaces help restore the functions of the limbs after a stroke. Furthermore, a recent meta-analysis has shown efficacy in therapy and transcranial stimulation.

Elizaveta Ivtushok


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