To be used in clinical trials.
"Nature Communications" on Dec 4 The researchers of the University of Queensland published in the journal "Nature Communications" on Dec 4.
Forbes magazine has also published the story of the test that could be used to diagnose all types of cancer.
Abu Ali Ibn Sina, who was a teacher at the Shahjalal University of Science and Technology in Sylhet, works as a research fellow at the University of Queensland under Prof. Matt Trau. Another researcher was Laura Carrascosa, a postdoctoral research fellow.
Abu Ali Ibn Sina. Photo courtesy of Sabiha Sultana via Facebook
What is it?
It is based on a unique DNA signature that appears on the World Economic Forum website.
Each cancer type, be it breast or bowel cancer, has different genetic and other features. Usually to test that detects one cancer may not work on another.
Researchers have long been looking for a commonality
"Our research has been found in cancer. The structure is the same in DNA from samples of breast, prostate and bowel cancers, as well as lymphoma.
"We wrote this DNA to less than ten minutes," they wrote.
Wrote in the World Economic Forum –
Current assessment of cancer requires a tissue biopsy – a surgical procedure to collect tissue from the patient's tumor.
Researchers have been looking for an earlier stage.
DNA to undergo considerable reprogramming.
This change is particularly evident in the distribution pattern of a tiny molecule called a methyl group, which decorates the DNA.
A normal cell DNA's distinct methyl pattern is crucial to regulating its machinery and maintaining its functions.
It is also responsible for turning genes on and off. Altering this pattern is one of the ways cancer cells regulate their own proliferation.
This methyl patterning has been studied before.
However, its effect in a solution has been never explored.
Using a high-resolution microscope, we translate DNA fragments into three-dimensional structures in water.
DNA in the water.
In the lab, gold particles are used to help detect biological molecules (such as DNA).
Molecular behavior in a way that causes visible color changes.
We discovered that DNA has a strong affinity towards gold, which means strongly binds to the gold particles.
This finding can be used to test that DNA in blood and tissue.
This requires a tiny amount of purified DNA.
It is possible to identify the cancerous DNA with the naked eye within five minutes.
The test also works for electrochemical detection – when the DNA is attached onto the flat gold electrodes.
It provides a higher relative electrochemical current signal in comparison to normal DNA.
This electrochemical method is highly sensitive and could also be used as a diagnostic tool.
Why this matters
DNA must be well.
"I know we've tested more than 200 tissue and blood samples, with 90 percent accuracy," they said.
"Accuracy is important to ensure there are fewer false positives – wrongly detecting cancer when there is none.
"The types of cancers we tested included breast, prostate, bowel and lymphoma. The DNA will respond to the same way. "
It is a promising start, but it is also necessary to prove its clinical use.
DNA signature. The next step is a large clinical study.
"We are assessing the possibility to detect different types of cancer from different body fluids.
"The researchers added." We are also considering whether the test could be based on the abundance of DNA signatures in body fluid during treatment.