Birth after a post-mortem uterus transplant: new tests in Brazil – Orange News


The doctors who performed in Brazil the first worldwide transplant of a deceased donor uterus that allowed the birth of a child told the AFP to prepare to repeat the operation on two women.

"The patients who were part of the initial group have already been chosen, have already done an in vitro fertilization," said dr. Dani Ejzenberg at the AFP in Sao Paulo, almost a year after the first delivery.

"We have good quality embryos and we are now waiting for compatible (uterine) donors to transplant," said the doctor, who received the AFP on Thursday.

But the medical team will also receive the go-ahead from the Brazilian authorities to generalize this technique, which is still in the experimental phase.

The dott. Ejzenberg, gynecologist at the University Hospital of São Paulo, is a member of the team that announced this week the success of this transplant conducted in September 2016 and made public on Wednesday by The Lancet.

The transplant was performed during an operation of about ten hours, in a 32-year-old woman born without a uterus. He received the uterus from a 45-year-old donor who died from a cardiovascular event and donated several organs.

In vitro fertilization embryos were transferred seven months after transplantation into the patient's uterus, which was immunosuppressed to prevent graft rejection.

And on December 15, 2017 a girl of 2.5 kilos was born, with a caesarean section, at 36 weeks of gestation. The first child to come into the world through the belly of a deceased donor. The uterus was removed from the mother during delivery to stop the very heavy immunosuppressive treatment.

"She is a very happy child and her mother is happy with this first" doctor, "says Dr. Ejzenberg.

"On December 15th, the child will have a year", says the doctor, and "develops in a completely normal way, both from the motor and neurological point of view".

– Lack of donors –

Prof. Luiz Carneiro, who led the transplant team, said he was proud to have given life to this technique with his colleagues.

"We are used to transplanting organs, but here we have a completely new perspective, as it has allowed us to give life," he says.

Previously, the only option for women with uterine infertility was the use of surrogate motherhood or adoption.

It was in Sweden in 2013 that the first child was born after a uterine transplant in a patient, but from a living donor.

Subsequently, 39 new transplants were performed worldwide, including 11 results in one birth.

But there are many more women in need of transplants than living women with uterine donation.

The medicine then focused logically on the possibilities of uterine transplantation of deceased women and on the chances of success for fertilization.

A dozen or so uterine transplant attempts have been made – in the United States, the Czech Republic, Turkey – but all have failed, up to the world premiere in Brazil.

"This successful demonstration has several advantages over living donor transplantation: it is based on a larger pool of potential donors, it is less expensive and avoids the risk to the living donor," said Dr. Srdjan Saso. from the department of obstetrics to Imperial College of London.


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