cerebral abnormalities detectable from the embryonic stage

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="Huntington’s is a rare, inherited, neurological disorder. It usually manifests itself between the ages of 30 and 50 by psychiatric, cognitive and motor disorders which worsen progressively. Biologically, this disease is caused by a mutation in the gene encoding a protein called huntingtin. A new study published in highlights brain abnormalities in human embryos carrying the mutation in the gene encoding huntingtin. ” data-reactid=”23″>Huntington’s is a rare, inherited, neurological disorder. It usually manifests itself between the ages of 30 and 50 by psychiatric, cognitive and motor disorders which worsen progressively. Biologically, this disease is caused by a mutation in the gene encoding a protein called huntingtin. A new study published in highlights brain abnormalities in human embryos carrying the mutation in the gene encoding huntingtin.

<h2 class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="A disease preceded by a long silent phase” data-reactid=”24″>A disease preceded by a long silent phase

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="“Sandrine’s teams Humbert (Inserm research director at Grenoble-Institut des neurosciences) and Alexandra Durr (university professor-hospital practitioner at Sorbonne University, at the Pitié Salpêtrière Hospital – AP-HP and at the Brain Institute) are interested in the early stages of Huntington’s disease and the long silent period that precedes the onset of symptoms. “, states a press release dated July 16, 2020. In France, among the carriers of the mutation in the gene encoding huntingtin, 6,000 people already show symptoms of the disease but nearly 12,000 are asymptomatic. It is in this context that Sandrine Humbert and Alexandra Durr looked at the earliest stages at which anomalies could be detected. “This is the first time that brain development abnormalities have been detected in this disease, they clarify. In addition, the anomalies are relatively large and extensive although we are not yet able to determine their direct consequences “. ” data-reactid=”25″>“Sandrine’s teams Humbert (Inserm research director at Grenoble-Institut des neurosciences) and Alexandra Durr (university professor-hospital practitioner at Sorbonne University, at the Pitié Salpêtrière Hospital – AP-HP and at the Brain Institute) are interested in the early stages of Huntington’s disease and the long silent period that precedes the onset of symptoms. “, states a press release dated July 16, 2020. In France, among the carriers of the mutation in the gene encoding huntingtin, 6,000 people already show symptoms of the disease but nearly 12,000 are asymptomatic. It is in this context that Sandrine Humbert and Alexandra Durr looked at the earliest stages at which anomalies could be detected. “This is the first time that brain development abnormalities have been detected in this disease, they clarify. In addition, the anomalies are relatively large and extensive although we are not yet able to determine their direct consequences “.

<h2 class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="Neuronal development is impaired from the embryonic stage” data-reactid=”26″>Neuronal development is impaired from the embryonic stage

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="Research teams studied brains from 13-week-old human embryos, donated by parents following medical termination of pregnancy. They compared the embryos carrying the mutation to those without to find notable differences. Sandrine Humbert exhibits them at Science and the Future[…]” data-reactid=”27″>Research teams studied brains from 13-week-old human embryos, donated by parents following medical termination of pregnancy. They compared the embryos carrying the mutation to those without to find notable differences. Sandrine Humbert exhibits them at Science and the Future[…]

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="Read more on sciencesetavenir.fr” data-reactid=”28″>Read more on sciencesetavenir.fr

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