Philippe Coutinho scored twice in the second half and Everton added a sublime third when Brazil recovered from a wrong start to beat Bolivia 3-0 in its America's Cup debut on Friday.
Both sides were poor in the first 45 minutes, but the game was briefly revived at the start of the second half, when Coutinho scored a penalty assisted by VAR.
Coutinho bagged for a second with a close-range header three minutes later, before Everton pulled home a third from outside the area five minutes from time.
"In the end, with a little patience, we opened things up, we had more ball and we created games," said captain Daniel Alves. "We deserved a great victory".
Brazil could have won the victory they wanted in their forerunner in Copa America, but the consequences were both the lack of atmosphere and the lackluster display.
The 43,442 fans who saw the game at the Morumbi stadium in San Paolo were not impressed and the team was called halfway through.
The entire game at the stadium, which was 70% full, was notable for the lack of atmosphere.
Coach Tite admitted that the players heard the whistles and said it was unrealistic to expect the fans to support a team that was not playing well.
"We felt!" Tite said. "The boys feel it, the coach feels it.
"Having been to big clubs, when you sometimes don't produce, don't expect fans to understand.
"When you pass the ball down your back, from full back to central defender to goalkeeper, the first thing you do is BOOOOOOO!"
"We need to understand: if we go ahead and create opportunities, they will applaud."
Venezuela, meanwhile, began its adventure in Copa America with a nervous 0-0 draw against Peru on Saturday
It was a stop-start case marked by two Peruvian goals scored after the VAR reviews.
The result means that both teams are tied to second place in Group A, behind the host nation of Brazil.
Copa America live stream – how to watch for free
Brazil vs Venezuela kicks off at 21:30 local time, which will be 01:30 Wednesday morning in the United Kingdom.
Live TV coverage can be found on Premier Sports 1 across the UK and Ireland.
A service subscription costs £ 9.99 per month, which Sky and Virgin customers can add to their packages.
Live streaming is available for the same price through the Premier Sports app and via your online player.
However, it's a way to watch Brazil vs Venezuela for free.
Some selected UK betting sites will provide free coverage of the game via their platforms.