Diabetes-damaged organs may recover this Protein

Late damage:

Damage to kidneys and lungs are common consequences of Diabetes. Through the control of blood glucose levels you can prevent, but by a targeted activation of DNA repair, such as Heidelberg scientists have found out.

Scientists at the University hospital Heidelberg and the German center for diabetes research showed in animal experiments for the first time that in mice with Diabetes an impaired repair of damage to the genetic material (DNA) is directly responsible for premature tissue aging, scarring and eventually loss of function of the organs responsible. The researchers used the repair mechanisms with the help of a certain the body’s own Protein (nRAGE) back in gear, stopped the process, the organs are recovered. The results are currently published in “EMBO Journal”.

“From a therapeutic point of view, it is particularly interesting that even scar tissue regained its ability to function to the part. Previously, it was thought this process is irreversible,” says senior author Professor Dr. Peter Nawroth, Medical Director of the University clinic for endocrinology, metabolism and Clinical chemistry Heidelberg, Germany. “This finding provides us for the first time, a promising approach to diabetic non-stop long-term damage in the future only, but may also heal.”

The metabolic disease Diabetes is scientists and Doctors still puzzle: So is not understood up to today, what disease damage, such as kidney failure, blindness or scarring of the lung tissue (pulmonary fibrosis) lead to mechanisms to be late. In the now published work, the Team around first author Dr. sc. hum. Varun Kumar, University hospital of endocrinology, metabolism and Clinical chemistry Heidelberg and the German center for diabetes research, for the first time in mice with Diabetes type I and Diabetes type II, the direct connection between the disturbed, for the cells of the body but essential for major DNA repair mechanisms, and increasing tissue damage to produce.

In 2017 published work of Kumar and colleagues had already discovered that the body’s own Protein RAGE (Receptor of Advanced Glycation end products) plays a key role in DNA repair and healing of tissues promotes damage. Now they examined the effect of the Protein in diabetic mice, they injected the genetic Blueprint for RAGE with the help of modified viruses in the lungs of the mice kidney. “This gene therapy has brought the success: The DNA repair returned to normal and the organs to heal,” says Kumar. As the scarred organ tissue, however, its function ability to back wins, is still unclear: “We suspect that it may be immigrant stem cells play a role,” said the doctor.

“Our results shed a completely new light on diabetic late damage: they are less a question of good or poorly adjusted blood glucose levels, but as a syndrome of impaired DNA repair,” says Nawroth. “Depending on the innate quality and efficiency of these repair mechanisms of the kidney occur, for example, or lung damage when the patient sooner or later. We must therefore find a way to help diabetic patients, the organs damaged at this level.”

(Last updated Saturday, 20.06.20 – 11: 14 PM – modified viewed:1455 times)

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