Exploring the possibility of a widely effective dengue vaccine

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Dengue is on the rise, with about 20,000 patients dying each year from this mosquito-borne disease, but despite ongoing efforts, a widely effective dengue vaccine is not available. The complex challenges, the current state of development of the dengue vaccine and whether an effective vaccine is even possible are the focus of a stimulating commentary published in Viral immunology, a peer-reviewed journal by Mary Ann Liebert, Inc., publishers.

The article entitled "Effective dengue vaccines: a pipe dream?" he was co-author of Lázaro Gil and Laura Lazo, Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba. The authors note the 10-fold increase in dengue cases compared to the previous decade and review efforts to develop a vaccine against dengue, including extensive animal studies and clinical studies that led to the approval of Dengvaxia by Sanofi-Pasteur.®. This vaccine, however, has a limited use profile, as it can actually increase the risk of severe dengue in some circumstances and cannot, for example, be given to children under the age of nine. In light of the re-emergence of viral diseases such as measles, rubella and polio, the authors suggest that a live attenuated dengue vaccine would probably require booster doses.

Based on past experimental evidence, the authors conclude that an effective dengue vaccine is possible, but it remains a substantial challenge and suggests rethinking several existing concepts in the ongoing effort to develop dengue vaccines.

David L. Woodland, PhD, Chief Editor of Viral immunology and an adjunct member of the Trudeau Institute of Saranac Lake, NY, states:

The recent approval by the Food and Drug Administration of the first dengue vaccine, Dengvaxia, represents an important step forward in the control of dengue. But the disease is complex and Dengvaxia can cause serious side effects in certain circumstances. The excellent review by Gil and Lazoh highlights the complex issues surrounding dengue virus vaccines ".

Source:

Mary Ann Liebert, Inc.

Reference to the magazine:

Lazo, L & Gil, L (2019) Effective dengue vaccines: a pipe dream? Viral immunology. doi.org/10.1089/vim.2019.0044

. (TagsToTranslate) Vaccine (t) Immunology (t) Mosquito

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