Identified 5 biomarkers that warn of an increased risk of breast cancer

Spanish researchers they have identified five biomarkers in blood that allow to detect in healthy women a greater risk of developing breast cancer in the future.

The aim of the study was to investigate how to detect breast cancer through molecular level in the blood before symptoms appear or before cancer can be detected by routine diagnostic tests.

The researchers compared serum and tumor and non-tumor tissue from 96 breast cancer patients with serum from 92 healthy patients, and analyzed 30 microRNAs (molecules that regulate the expression of certain genes).

Of the microRNAs they analyzed, the researchers identified five that reveal whether a serum sample belongs to a patient with breast cancer or a healthy patient.

In 2019, more than 30,000 new cases of breast cancer were diagnosed in Spain, the most frequent among women around the world and, in Spain, the leading cause of death in women between 40 and 55 years old.


It is important to insist that when breast cancer is detected early in the earliest stages, the cure rate is very close to 100%. Specifically, in stage I, when the tumor is small and has not spread, survival is almost 100%, although it drops to 24% in more advanced stages.

Early diagnosis continues to be essential to improve the chances of cure and, therefore, getting to know which people are at higher risk of developing breast cancer in the future will allow an individualized and more exhaustive follow-up to be carried out that makes it possible to detect early breast cancer. possible tumor formation.

In the study, published in the journal Frontiers in OncologyScientists from the Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Research Institute (VHIR), IOB Oncology Institute, University Clinic of Navarra, CAP Vallcarca-Sant Gervasi of Barcelona and CIBERONC (CIBER of Oncology formed by 50 research groups from 27 institutions among hospitals, universities and research centers throughout Spain).

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