Health Immunity Other tasks .. Learn about its relationship to...

Immunity Other tasks .. Learn about its relationship to mental health and depression



Al-Shaimaa Ahmed Farouk


Published in :
Thursday, May 21, 2020 – 3:55 PM
| Last updated :
Thursday, May 21, 2020 – 3:55 PM

There was a lot of talk about immunity and its importance in the human body, and it became one of the important words in the search engines, after the spread of the new Corona virus, and immunity is the main player in defense during the battle of the virus inside the body.

And immunity is the key to fighting infection, but in reality it has more than one role. It plays a key role in cases such as diabetes, cancer, and heart disease. More surprising is that it constitutes our thinking. This was the content of the report published in Psychology Today by Uster. Perlmuter, a doctor specializing in internal medicine, concerned with mental health and behavior change, is the author of “Brainwashing”.

He said that to change our thoughts, the immune system must reach its highest levels in the brain, we know information about neurons and others, but do we know much about immune cells, the brain actually has its own immune cells, called these small glial cells, and researchers discovered Small glial cells about a century ago, yet we only recently understood their great importance.

What are small glial cells?

Small glia are associated with a wide range of brain diseases, including Alzheimer’s, Parkinson’s, a disorder that affects the nervous system and affects movement, multiple sclerosis, and many others, where these brain problems are characterized by nerve cell damage and death, and glial cells are involved in repairing neurons, as well as keeping them on Alive.

The link between small glial cells and our thoughts becomes clearer, when we understand that our thoughts and actions are a reflection of the behavior of the brain, and the core of these wires consists of neurons, which are affected by the microglia, so the presence of healthy glia cells is necessary for healthy awareness, and Dr. Perlmutter pointed out that these The cell is very moody.

Small glia cells, such as the reserve forces, are inactive until they are needed, and when they get the right signal, they undergo a dramatic shift, including changing the shape and moving to the place they need and making a specific set of chemicals.

Once exposed to a certain group of molecules in the brain, small glial cells become specialized, and one of these specialized forms is called “M2 microgial” cells. These help the growth of new neurons and heal brain damage. When they receive other signals, they can turn into another specialized form called The M1 microgial cells appear to help remove pathogens such as bacteria from the brain.

What is the link between these cells and our mental health?

In the presence of inflammation, small glial cells preferentially switch to the subtype “M1” and then these cells produce more inflammation, and this subsequently causes problems, because elevated levels of inflammation are associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s, so recently This inflammation itself mood disorders, as some studies have indicated that these cells and what they produce if they malfunction may be a cause of depression.

Over the past few decades, various experiments have confirmed that inflammation contributes to depression, and early research noted that patients receiving interferon due to hepatitis showed symptoms of depression, and it was confirmed that inflammatory markers in the blood were higher in people with depression.

Glial cells can be seen as signal amplifiers, when you hear a message they are widely promoted, and this is especially important for inflammation and its final effects, and when inflammation reaches the brain, it stimulates small glia cells to cause more inflammation, and this harms neurons, More importantly, they may actually inhibit their creation, because low production of new neurons (called neuronal formation) in a particular part of the brain may have a role in depression.

Our cognitive ability and mood is a reflection of the behavior of our minds, which is greatly influenced by our immune systems, especially cells called microglia, and these cells are activated differently through the signals they receive, and when exposed to inflammation, small glia cells begin to increase the generation of inflammation in the brain, Which is associated with cognitive decline and depression.

The most globally relevant approaches to reaching this goal include avoiding immune problems and their consequences, avoiding unhealthy diets, raising moderate exercise levels, adequate sleep, and stress reduction techniques, because all of these methods are solutions to keep immunity from any negative effects.

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