Isco is a primary target for Chelsea and Arsenal this January as an exit of Real Madrid looms.
The Spanish midfielder has fallen with manager Santi Solari since the departure of Julen Lopetegui.
And a clean break in the next month's transfer window seems to be on the cards.
Unai Emery and Maurizio Sarri are particularly eager to acquire Isco, report the Sun, with the next destination of the Spanish national almost certainly in the Premier League.
The Blues could imagine the possibility of rooting the Gunners due to the fact that Emery was in Valencia when they sold Isco to Malaga.
The 26-year-old has more than three years remaining in his contract, but with Solari installed as permanent director at the Bernabeu, Isco could be available for a lucky suitor.
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Everton coach Marco Silva has confirmed he wants to make Andre Gomes' seasonal loan from Barcelona, but the midfielder's contract with the Spanish giants has an attractive £ 90 million buyout clause.
Jose Mourinho refused to discuss the interest reported by Manchester United in Kalidou Koulibaly, saying: "He's a player from Napoli, and I'm not talking about players from other clubs." The Red Devils have been linked with a move of 94 million. pounds for the Napoli striker as the January transfer window approaches.
Arsenal is leading the race for the Lille wing 27 million euros Nicolas Pepe, as reported in France.
Real Madrid midfielder Isco told teammates that he is ready to leave for Manchester City in January, according to Spanish media.
The in-demand Ajax pair Frenkie de Jong and Matthijs De Ligt want to stay together as they are drawn by the most important clubs, according to reports from the Spanish media. Both players have been strongly linked to important clubs like Barcelona, Paris Saint-Germain and Manchester City and now they could explore the prospect of a joint move.
Fabinho speculated that he had decided to leave Liverpool – only a few months after a summer trip from Munich.
Chelsea and Napoli could negotiate an exchange agreement with central defender Andreas Christensen and right-back Elseid Hysaf, according to an Italian report.