Mauro Mandzukic sent Juventus 11 points ahead in Serie A while he cut out Inter Milan in the Derby d'Italia in Turin.
A hard-fought match was resolved with the header of the 66th minute of Mandzukic, while the Croatian once again demonstrated the man for the big occasion.
Victory means that Juventus remains unbeaten after 15 league games, winning 14, and no team in the first five European Championships has ever scored better at this stage of a campaign.
Italian giants Juventus maintained the unbeaten Serie A season on Friday night
Mario Mandzukic (left) scored the winner against Inter after an assist by Joao Cancelo
The goal was a good header on the far post: the eighth away goal from Mandzukic this season
Inter was left to reflect on the missed opportunities, among which stands out a shot by Roberto Gagliardini who hit a post in the first half.
Juventus was immediately protagonist in the early stages of the game. Cristiano Ronaldo would have spent a quiet evening, but he started brilliantly, first producing a giant step, then a cross from a point and a half for Paulo Dybala who headed the header just above.
Shortly thereafter, another neat move saw Dybala play and Samir Handanovic had to help his shot up over the bar. From the resulting corner Leonardo Bonucci has diverted an enticing cross.
With several occasions in which he was begged, Juventus was almost punished just before half-hour when Inter hit a stake.
Matteo Politano enters from the right and notes Mauro Icardi. With the back to the door, the Argentine put the ball out for Gagliardini, whose shot cannonaded back out of the post and into the grateful arms of Wojciech Szczesny.
The occasion highlighted the danger that the Politano has placed on the right, but Juventus has been slow to take note.
Mandzukic kept an eye on the ball as he beat Slovenian Samir Handanovic in the Inter goal
Inter, whose players seemed disheartened after being left behind, are now 14 points behind leaders Juve
Juventus supporters seemed to be having fun while celebrating taking command on Friday
Inter came back just a few moments after Politano put the ball back for Ivan Perisic, but this time the Croatian opened the gap.
Juventus had the chance to take the lead just before the interval when the ball was interrupted for Rodrigo Bentancur, but the impressive Marcelo Brozovic made a good shot to send the ball into the corner.
The recovery began with a chance for Inter after Blaise Matuidi dangerously gave the ball to the edge of his area, but the unsuspecting shot by Politano was blocked by Bonucci.
The game soon turned into a disgusting yellow card in the back, before Juventus hit the 66th minute.
And it was a goal that came out of Juve's favorite playbook, with Joao Cancelo sending in a deep cross and Mandzukic who was in front of Kwadwo Asamoah on the far post to apply the header.
Inter soon had a chance to hit but Perisic's free-kick from a dangerous position was deflected by Matuidi as he jumped up from the wall.
Instead, a second of Juventus seemed more likely than a draw as the game lengthened and were able to probe Inter's defense on the counterattack.
In the end they could not put Handanovic in trouble again, but Mandzukic had already done enough to keep the three points in Turin.
Domestic players celebrated in front of their fans after the final whistle at the Allianz Stadium
Juventus star Cristiano Ronaldo smiled as he waved at the end of the evening