Tottenham Hotspur said it was "unlikely" that midfielder Mousa Dembele will play again in 2018 after suffering an ankle ligament damage.
The 31-year-old injured his right ankle during Saturday's 3-2 win against the Wolves.
The Spurs boss, Mauricio Pochettino, said: "We hope it will be ready by the beginning of January".
Tottenham visited Crystal Palace on Saturday without Jan Vertonghen, an injured defender, and left-back Danny Rose (groin).
Pochettino, who has been at the Spurs since 2014, has been strongly linked to the Real Madrid champions of Europe.
The La Liga giants fired Julen Lopetegui last month after a 5-1 defeat by Barcelona, with Santiago Solari currently in a provisional position.
"I'm so focused on Tottenham," said the 46-year-old. "A voice appears every day.
"The most important thing is that I'm focused on Tottenham.
"Our fans need to know this and, of course, Daniel Levy.
"I'm focused on Tottenham, working hard to get what we want, voices are voices and always happen".
Tottenham has used Wembley as a home from the start of the 2017-18 season, with Pochettino calling on fans to be "grateful".
"We have to be grateful to Wembley, because without Wembley now, let's play where?" He said.
"Of course, we can not blame Wembley and I think we have to be grateful because we can compete in London, near White Hart Lane, near our training ground and this is a huge advantage for us.
"Of course, afterwards you feel disappointed because it's not your home, it's not your home.
"But I think the legacy of [chairman] Daniel [Levy] and the board and what the club is doing for the club for the rest of our lives and for the next generation of Tottenham fans, it's huge.
"That's why we have to be patient because if we wait a few weeks longer, or months, to finish the stadium."
The new Spurs Stadium, on the site of their old land in White Hart Lane, will not be open until at least January 2019.
"I think for our fans, they need to start creating in their minds and think that one more day at Wembley is one less day to be in our new stadium," added Pochettino.
"If we can get there and start playing in our new stadium in a great position, being involved in all competitions, I think our fans in our new stadium will be decisive and decisive to try and win something."