New reference cell atlases of the intestine, kidney and placenta, essential for deciphering human diseases

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Los healthy tissue atlas they play a vital role in biomedical research by serving as a reference that can be compared to diseased samples. These atlases can help scientists understand what goes wrong before a disease progressesknowledge that, in parallel, can provide key information on the development of early stage treatments pathological

In this line of knowledge, Nature publishes three studies in which the reference cell maps are presented for the human intestine, kidney and maternal-fetal interface (element in which the placenta and maternal cells coexist). These reports are part of a larger package of articles from the Human BioMolecular Atlas Program (HuBMAP), a consortium of more than 400 scientists from more than 40 global institutions.

jobs discover new information about how cell types are organized and how they interact in different human tissues and organs: how cells individual cells of the organism live and work together in what are called ‘cellular neighborhoods’, information that becomes an indispensable resource for studying biology and human diseases.

Through tools -developed by the HuBMAP consortium, founded by the National Institutes of Health (NIH)- that allow assembling spatial maps of components Cellular molecules, including RNA, proteins, and metaboliteswithin tissues and organs at the single cell level, reference cell atlases have been generated for the human intestine, kidney, and placenta-connected tissues.

“The three HuBMAP atlases have the potential to advance our understanding of pathology by define the spatial location of cell states linked to the disease,” according to Roser Vento-Tormo y Vilarrasa-Blasi rose garden in an accompanying News & Views article, from Nature. “They anticipate the generation of more atlases in other tissues, but note that even more needs to be done. tests on more samples to establish strong associations between cellular organization and function in health and disease.”

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