There was a 40% increase in the number of people who died alcohol-specific deaths in Northern Ireland since the registrations began in 2001.
The Office for National Statistics reported the figures as part of a report on alcohol-related deaths across the UK.
Data from the Northern Ireland Institute of Research and Statistics show that 303 people died directly from alcohol in 2017, the highest since records began.
The records show that 178 people died from alcohol in Northern Ireland in 2001, while the lowest ever recorded was 2003 with 175 deaths.
Alcohol deaths have increased for both men and women with 61 women dying of alcohol in 2001, compared to 91 in 2017.
In contrast, 212 men died as a direct result of alcohol in Northern Ireland in 2017, the highest ever recorded, compared to 117 in 2001.
The all-alcohol-related mortality rates among women across the UK are at the highest recorded level.
In the United Kingdom, in 2017, 2564 women died as a direct result of alcohol, compared to 5,133 men, the overall mortality rate was similar to the highest levels recorded in 2008.
Mortality rates across the UK among men tend to be twice that of women.
Scotland continues to have the highest rate of specific alcohol deaths, but it is the only country that has seen a statistically significant decrease since 2001, with deaths declining by 21%.
Karen Tyrell, director of external affairs at Addaction, a body for mental health, drugs and alcohol, said that older drinkers were becoming a growing problem.
"We know that alcohol is a problem for the over 50s and we have to do a lot more to reach this group in a way that works for them.For older drinkers, alcohol often creeps in and gradually assumes a more central role in the day-day life, "he said.
"The people we work with often talk about alcohol as a way to deal with loneliness, isolation and the sense of loss that sometimes goes with retirement and moves into a new phase of life.
"The good news is that everyone can change their relationship with alcohol.Thousands of us do it every month.There is a way" to do it ". It's different and worth it. If you need help or support, reach ".
Belfast Telegraph Digital