They find key clues to address the disease that causes the disappearance of menstruation

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“For the first time in history, we have managed to decode the cellular mechanisms y molecular of the Asherman’s syndrome during the secretory phase of the menstrual cycle. This achievement represents a milestone of great relevance in the understanding of this pathology, with a potential significant impact on the medical practice“, points out to this medium Carlos Simonprofessor of Obstetrics and Gynecology at the University of Valencia.

Together with his research team from the University of Valencia, the Health Research Institute (Incliva) and the Carlos Simón Foundation, he has published data from a work in Nature Communications that describes for the first time the cellular alterations responsible for Asherman syndrome. at the single cell level.

This syndrome constitutes a rare disease characterized by intrauterine scar tissue formation which causes menstrual disorders and infertility. Adhesions may occur in only a small part of the uterus, or be more extensive and severe, causing the front and back walls of the uterus to stick together.

women with Asherman’s syndrome They suffer pain in the area, irregularities in the menstrual cycle, such as reduced or absent bleeding, frequent spontaneous abortions and infertility. In most cases, the disease appears after surgery in the uterus, although in other cases, a serious pelvic infection unrelated to surgical procedures can lead to its development.

All this reflects the high impact that the disease has on women both physically and mentally. Despite the low estimated prevalence, as stated by the Committee for Orphan Medicinal Products of the European Medicines Agency, four in every 10,000 women, it is a debilitating condition due to the pain, spontaneous abortions, infertility they experience and the psychological distress that they experience. All this triggers together.

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