Some Virgin Atlantic pilots will hit from December 22 to Christmas Day in a trade union recognition dispute, the Union said professional pilots.
The union, which represents about a third of the airline's pilots, said it had been excluded from the talks on the proposed changes to the benefits of the pilot.
He said that this was the first of a series of strikes from one to four days he wants to keep until the dispute is resolved.
Virgin Atlantic said it did not expect any interruption of its program.
The PPU said that 72% of Virgin Atlantic members went to the ballot, and 71.5% of those who voted supported the strike.
The other strikes are scheduled from December 30th to January 2nd and from January 4th to January 7th inclusive.
PPU spokesperson Steve Johnson, a former Virgin pilot, said the union has been conducting legal action for two years to get recognition from Virgin.
He said it was the "last straw" when the union was left out of the negotiations after Virgin Atlantic "has consistently refused to recognize the PPU as a legitimate and independent union".
"We hope that Virgin will recognize the mandate our members have given us, and help prevent strike action by recognizing the PPU and stopping the benefits review that is so damaging to our members' long-term security," Johnson said.
"Our door is – and has always been – open to Virgin to take the necessary steps to avoid any interruption for Christmas travelers".
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Virgin Atlantic said that a "small number" of its pilots had voted for an industrial action.
"Our top priority is to ensure that all our customers can continue their journeys as planned this Christmas, and we are working hard to protect all their journeys," reads a statement.
The airline operates flights from London Heathrow, London Gatwick, Manchester, Glasgow and Belfast.
Fly to destinations in the United States, Asia, Africa and the Caribbean, as well as Dubai and Cancun.