What is the best vaccine against Covid? Differences between Janssen, Pfizer, Moderna and AstraZeneca

The Public Health Commission has approved four vaccines to fight the coronavirus pandemic in Spain. Doses of Pfizer, Astrazeneca, Modern and Janssen have been in charge of Spain has exceeded 70% of the population vaccinated with the complete regimen.

Each citizen who has attended their appointment with the immunization has received one vaccine or another depending on their age. All are aimed at reducing the possibility of contagion and, in the event of transmission, that the disease is not serious. However, in addition to the obvious similarities, each vaccine formulated by different pharmaceutical companies has differences between them.

One of the most obvious differences between vaccines is the number of doses. The only single dose is Janssen. The rest requires two punctures, unless the person in question has already passed the coronavirus, which with one dose would achieve the complete pattern in Spain.

Another difference between vaccines is the time between the first dose and the second. The Pfizer-BioNTech vaccines and AstraZeneca require an interval of 21 days between the first and second dose, while the serum of Modern needs 28 days.

Percentage of effectiveness of vaccines against Covid

A value that must be taken into account by the recipients of the coronavirus vaccine is its efficacy. In general terms and when moderate cases are included, Pfizer-BioNTech and Moderna are around 95 percent effective, AstraZeneca 80 percent and Janssen 66 percent.

Differences between mRNA and adenovirus vaccines

Pfizer and Modern are based on Messenger RNA. This means that what the vaccine contains is nucleic acid that, when a person is vaccinated, enters the cell and is translated into the spike protein of the SARS-CoV2 virus. The immune system recognizes it and generates antibodies and an immune response.

Conversely, Janssen and AstraZeneca It is a virus that has been modified in such a way that it cannot make you sick, nor replicate, nor join your DNA, because very important parts of the genome of that virus have been removed.

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