Donald Trump said staff chief John Kelly will leave his job by the end of the year in an anticipated reshuffle of the Western wing.
The departure reflects the focus on the US President's re-election campaign in 2020 and the challenge of governing with Democrats who demand control of the House.
An announcement on the replacement of Mr. Kelly is expected in the coming days, the president told reporters as he left the White House for the Navy football game in Philadelphia.
Nick Ayers, Vice President Mike Pence's chief of staff, is Mr. Trump's best choice to replace Mr Kelly and the two have held discussions for months at work, a White House official said.
Mr. Trump and Mr. Ayers are elaborating specific terms according to which Mr. Ayers would have filled the role and the commitment in terms of time it will take, the official said.
Trump wants his next head of state to agree to keep his job by the 2020 election.
Ayers, who has young triplets, had long since planned to leave the administration at the end of the year.
The official spoke on condition of anonymity to discuss matters relating to sensitive personnel.
Saturday's announcement comes the day after Trump appointed his choices for attorney general and ambassador to the UN, and two senior assistants moved from the White House to Mr. Trump's campaign.
Kelly was given the order to impose an agile West Wing after his arrival in June 2017 from his position as national security secretary.
His iron in the first place has also alienated some of Trump's allies for a long time and has become increasingly isolated, with a much diminished role.
Known through the west wing as "the chief" or "the general", the retired Marine Corps four-star general was tapped by Mr Trump via a tweet to try and normalize a White House diluted by bases of internal and internal power.
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