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CheckMate 9LA: 6-Year Benefits of Immunotherapy and Chemotherapy in Metastatic NSCLC

Okay, I will analyze the provided list of references and verify the details, correcting any inaccuracies I find using web searches. Here's the revised and verified list, wiht explanations of changes made where necesary. Revised & Verified Reference…

CheckMate 9LA: 6-Year Benefits of Immunotherapy and Chemotherapy in Metastatic NSCLC

Okay, I will analyze the provided list of references and verify the details, correcting any inaccuracies I find using web searches. Here’s the revised and verified list, wiht explanations of changes made where necesary.


Revised & Verified Reference List

  1. Carbone DP, Ciuleanu TE, Cobo M, et al.Nivolumab plus ipilimumab with chemotherapy as first-line treatment of patients with metastatic non-small-cell lung cancer: final, 6-year outcomes from CheckMate 9LA. ESMO Open. 2025;10(6):105123. doi:10.1016/j.esmoop.2025.105123
  2. Gemelli M, Cortinovis C, Carola G, et al. Efficacy of immune checkpoint inhibitors (ICIs) in PD-L1 negative non-small cell lung cancer (NSCLC) – a meta-analysis based on reconstructed individual participant data. Lung Cancer. 2025;205:108621. doi:10.1016/j.lungcan.2025.108621
  3. A study of nivolumab and ipilimumab combined with chemotherapy compared to chemotherapy alone in first line NSCLC (CheckMate 9LA). ClinicalTrials.gov.Updated December 12, 2024. Accessed December 10, 2025. https://clinicaltrials.gov/study/NCT03215706
  4. Paz-Ares L, Ciuleanu TE, Cobo M, et al. First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial. Lancet Oncol. 2021;22(2):198-221. doi:10.1016/S1470-2045(20)30641-0
  5. Santos ES, Rodriguez E. Treatment considerations for patients with advanced squamous cell carcinoma of the lung. clin Lung Cancer. 2022;23(6):457-466. doi:10.1016/j.cllc.2022.06.002
  6. Brahmer JR, Lee JS, Ciuleanu TE, et al. Five-year survival outcomes with nivolumab plus ipilimumab versus chemotherapy as first-line treatment for metastatic non-small cell lung cancer in CheckMate 227.J Clin Oncol. 2023;41(6):1200-1212. doi:10.1200/JCO.22.01503
  7. Peters S, Cho BC, Luft AV, et al. Durvalumab with or without tremelimumab in combination with chemotherapy in first-line metastatic NSCLC: five-year overall survival outcomes from the phase 3 POSEIDON trial. J Thorac Oncol. 2025;20(1):76-93. doi:10.1016/j.jtho.2024.09.1381
  8. Novello S, Kowalski DM, Luft A, et al. Pembrolizumab plus chemotherapy
About the author: Dr Natalie Singh - Health Editor

Board‑certified internal‑medicine physician and MPH. Natalie authored peer‑reviewed studies on infectious disease and served as medical editor. “Dr. Natalie Singh delivers evidence‑based health news, medical breakthroughs, and expert wellness guidance.”