Switching to a strictly low-plastic diet can slash urinary levels of specific plastic-associated chemicals by up to 60 percent in just seven days, according to a randomized controlled trial published in Nature Medicine. Led by researchers at the University of Western Australia, the study demonstrates that minimizing contact between food and plastic packaging or kitchenware directly reduces human exposure to potentially disruptive synthetic compounds.
The PERTH Trial: Investigating Dietary Plastic Exposure
To understand population baseline exposure, the research team initially examined 211 participants in Perth, Western Australia, finding that 100 percent of individuals excreted at least six plastic-associated chemical metabolites daily. Building on this cohort, scientists launched a randomized controlled trial involving 60 participants to test targeted lifestyle interventions. According to principal investigator and senior author Michaela Lucas, a clinical immunologist at the University of Western Australia, participants consumed everyday items like pasta, meat, fruit, and snacks, but sourced exclusively through food producers who eliminated plastic contact from paddock to plate.
Phthalates, Bisphenols, and Food Packaging Pathways
Modern manufacturing utilizes more than 16,000 chemicals to produce plastics, many of which function as hormone disruptors in the human body. The trial focused heavily on phthalates and bisphenols, including BPA and BPS. Co-first author Amelia Harray noted that dietitians collaborated with over 100 farmers and food producers to modify handling and packaging processes. While changes to personal care products produced minimal shifts in chemical excretion, strict adherence to low-plastic foods yielded the most pronounced reductions in urinary metabolite levels within the one-week timeframe.
Frequently Asked Questions
What specific chemicals were measured in the study?
The research measured urinary metabolites belonging to major plastic-associated chemical classes, specifically phthalates and bisphenols such as BPA and BPS.

How long did the dietary intervention last?
The randomized controlled trial required participants to maintain the low-plastic dietary intervention for exactly seven days.
Did participants restrict their overall food intake?
No. Participants maintained their normal energy intake by consuming everyday foods like meat, dairy, produce, and snacks, provided the items avoided plastic contact during production, packaging, and preparation.
Related reading