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Coffee Consumption Linked to Improved Outcomes in Colon Cancer Patients: A Meta-Analysis
A research team led by Professor Cho Jong-kwan at the East-West Cancer Centre of Seoul Oriental Medicine Hospital, Daejeon University, analyzed the relationship between coffee consumption and long-term prognosis in 5,442 patients with colorectal cancer. The researchers conducted a meta-analysis, reviewing data from four prospective cohort studies investigating coffee consumption in colorectal cancer patients. These studies were identified through searches of PubMed, EMBASE, and the Cochrane Library up to May 2024 (corrected date – see explanation below). The analysis included patients with colon cancer across all stages, from stage 1 to stage 4.
The research team used overall survival time, progression-free survival time, and cancer recurrence as key indicators to compare outcomes based on coffee consumption levels. They also analyzed the effects of caffeinated and decaffeinated coffee, as well as variations in daily intake.
The results showed that colorectal cancer patients who drank coffee had considerably higher overall survival rates and progression-free survival rates, and a lower risk of cancer recurrence. For each additional cup of coffee consumed per day, the risk of death, disease progression, and recurrence tended to decrease by approximately 4%.
The beneficial effect of coffee consumption was particularly pronounced in patients with stage 3 colon cancer, where coffee consumption was associated with a more than 40% reduction in the risk of death.
Similar trends were observed when analyzing regular and decaffeinated coffee separately. Both types demonstrated critically important correlations with survival rates and recurrence risk. The research team suggests that these results indicate the benefits of coffee are not solely attributable to caffeine.
Professor Cho Jong-kwan stated, “This analysis suggests that the
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