Eric Dane, ‘Grey’s Anatomy’ Star, Dies at 53 Following ALS Battle

Eric Dane, best known for his role as Dr. Mark Sloan on the hit medical drama “Grey’s Anatomy,” has died at the age of 53 after a battle with amyotrophic lateral sclerosis (ALS), his representatives confirmed on Thursday, February 19, 2026 [USAToday]. He announced his diagnosis in April 2025 [CBS News].

A Courageous Battle

Dane passed away on Thursday afternoon surrounded by his wife, actress Rebecca Gayheart, their two daughters, Billie and Georgia, and close friends [CBS News]. His family described him as a passionate advocate for ALS awareness and research during his illness.

Career Highlights

Dane rose to prominence playing the charismatic Dr. Mark “McSteamy” Sloan on “Grey’s Anatomy” from 2006 to 2012, with a guest appearance in 2021 [USAToday]. He also starred in the HBO drama “Euphoria” as Cal Jacobs, and had roles in films such as “X-Men: Last Stand,” “Burlesque,” “Marley & Me,” and “Valentine’s Day” [CBS News]. Between 2014 and 2018, he played Tom Chandler in the post-apocalyptic series “The Last Ship.”

ALS Advocacy and Recent Challenges

Despite the challenges posed by ALS, Dane remained committed to raising awareness and finding a cure for the disease [TODAY]. He partnered with “I Am ALS” on its Push for Progress initiative [TODAY]. Just weeks before his death, he had to withdraw from an ALS Network gala due to the physical realities of his condition [USAToday]. He previously missed a scheduled appearance at the 2025 Emmy Awards due to a fall that required stitches [USAToday].

Tributes from Hollywood

Following the news of his death, tributes poured in from fellow actors, including Patrick Dempsey, Ashton Kutcher, Alyssa Milano, John Stamos, Nina Dobrev, Maria Shriver, Shonda Rhimes, and “Euphoria” creator Sam Levinson [USAToday].

Family and Legacy

Eric Dane is survived by his wife, Rebecca Gayheart, and their two daughters. The family has requested privacy during this difficult time [CBS News]. Gayheart and Dane married in 2004 and briefly separated in 2017, but ultimately remained together [TODAY].

About ALS

ALS, also known as Lou Gehrig’s disease, is a progressive neurodegenerative disease that affects the nervous system, leading to muscle weakness and eventual loss of control [CBS News]. Approximately 30,000 people in the United States are affected by ALS at any given time [CBS News]. The life expectancy following diagnosis is typically three to five years [CBS News].

A GoFundMe campaign was established by friends of the family to support Dane’s daughters, raising over $275,000 towards a $500,000 goal [NBC News].