The Arizona Cardinals travel to face the Los Angeles Chargers on Sunday, September 13, 2026, at SoFi Stadium in Inglewood, California, with kickoff scheduled for 4:25 p.m. This Week 1 matchup brings together an Arizona offense that led the NFL in passing targets last season and a Los Angeles squad operating under new offensive coordinator Mike McDaniel.
How to Watch Cardinals vs. Chargers
Viewers preferring to stream the action online can use Paramount+, which provides live streams of regional CBS broadcasts.
Betting Odds and Market Movement
The betting market heavily favors the home team as the regular season opens. The game carries an over/under total of 47.5 points. Los Angeles enters with a moneyline of -515, while Arizona sits at +389, and early betting data shows 96 percent of moneyline wagers backing the Chargers.
Key Players to Watch
Arizona’s backfield situation remains a central storyline heading into kickoff. Rookie Jeremiyah Love is working his way back from a high ankle sprain sustained in the preseason. While the team is optimistic Love will play, his touches may be managed rather than a full workload. In the passing game, tight end Trey McBride remains a focal point after exceeding 56.5 receiving yards in eight of his last nine outings, averaging 84.8 yards per game.
In the backfield, running back J.K. Mitchell has been fully cleared for Sunday after participating fully in Friday’s practice without an injury designation. Mitchell is expected to operate in a change-of-pace role alongside backfield mate Omarion Hampton within McDaniel’s offense. On defense, pass rusher Khalil Mack enters the game two tackles for loss away from reaching 150 for his career.
Keep reading