US and Israel Launch Major Assault on Iran, Global Reactions Mount

After weeks of escalating tensions, the United States and Israel launched a major joint strike on Iran on Saturday, March 1, 2026, targeting key military and government sites. The operation, dubbed “Operation Epic Fury” by the US, has triggered a swift response from Iran, with missile and drone attacks directed towards Israel and US military bases in the Gulf region. The conflict has already resulted in casualties, including three US service members killed and five wounded, according to US Central Command.

Key Developments

• Joint US-Israel Strike: Waves of attacks targeted sites across Iran, including those linked to Supreme Leader Ali Khamenei and President Masoud Pezeshkian. The Times of Israel reports that other top regime and military commanders were as well targeted.
• Iranian Retaliation: Iran has responded with missile and drone attacks targeting Israel, Bahrain, Kuwait, Qatar, the United Arab Emirates, and Jordan. BBC News details this retaliatory action.
• Casualties: Three US service members have been killed, and five seriously wounded, as a direct result of the attacks. ABC News provides the latest updates on casualties.
• Key Iranian Figures Killed: Ayatollah Ali Khamenei, Iran’s Supreme Leader, was killed in the airstrikes, confirmed by both US President Donald Trump and Iranian state television. PBS News and BBC News report on this development. Commander of Iran’s Islamic Revolutionary Guard Corps, Gen. Mohammad Pakpour, and Iranian defense minister Aziz Nasirzadeh were also killed.

Trump’s Stance and Objectives

US President Donald Trump announced the commencement of “major combat operations in Iran,” stating the goal is to prevent Iran from developing nuclear weapons and to dismantle its missile capabilities. He called for Iranian forces to lay down their arms and urged the Iranian people to overthrow their government. The Times of Israel highlights Trump’s call for regime change.

Regional Impact and Ongoing Operations

The conflict is rapidly escalating, with Israel continuing to strike targets in Tehran. The situation remains fluid, and further developments are expected as Operation Epic Fury continues. ABC News is providing live updates on the evolving situation.

Key Takeaways

• A major joint US-Israel assault on Iran has commenced.
• Iran has retaliated with attacks on Israel and US regional allies.
• Several high-ranking Iranian officials, including Ayatollah Ali Khamenei, have been killed.
• US casualties have been reported, with three service members killed and five wounded.
• The situation is highly volatile and rapidly evolving.