Jim Gaffigan Continues to Use Mounjaro for Weight Management
Comedian Jim Gaffigan is continuing to use the GLP-1 medication Mounjaro as part of his health regimen, following a 50-pound weight loss. Gaffigan initially discussed his weight loss journey in his 2024 comedy special, “The Skinny,” and has since been open about his experience with the medication.
Not Focused on Further Weight Loss
Although acknowledging the positive impact of Mounjaro, Gaffigan clarified that he is not currently using it with the goal of losing additional weight. He explained on the March 24 episode of Craig Melvin’s podcast, “Glass Half Full,” that he continues to take the medication due to a concern about regaining weight and experiencing nausea if he stops. Source
Managing Compulsive Eating Behaviors
Gaffigan described Mounjaro as helping him to eat “like a human, as opposed to a dog,” referencing a past pattern of compulsive eating. He recalled instances of consuming multiple boxes of Triscuits in a single morning with his wife. Source He hopes the medication is “the miracle drug that people think it is,” particularly for suppressing compulsive behaviors. Source
Previous Discussions on Weight Loss
In a May 2025 appearance on TODAY with Jenna & Friends, Gaffigan expressed feeling better overall as a result of his weight loss, noting both the health benefits and his improved well-being. Source He jokingly acknowledged that his weight loss involved the use of appetite suppressants, stating, “It is great. It’s beneficial.” Source
Addressing Misconceptions
Gaffigan has addressed public speculation about his weight loss, jokingly responding to accusations of using Ozempic by stating he is on Mounjaro, “which is better, right? Since it sounds like an Italian restaurant.” Source