The Detroit Lions enter Week 5 of the 2026 NFL season as 4.5-point road favorites against the Arizona Cardinals for their October 11 matchup at State Farm Stadium. Kickoff is set for 1:25 p.m. MST (4:25 p.m. ET) with a televised broadcast on FOX and streaming available on Fubo, according to reporting.
What are the latest point spreads and betting lines for Lions versus Cardinals?
BetMGM Sportsbook lists the Detroit Lions as 4.5-point favorites over the Arizona Cardinals for the Sunday game. DraftKings Sportsbook shows a nearly identical spread, listing the Lions at -4.5 (-105) and the Cardinals at +4.5 (-115). Bettors weighing the moneyline will find Detroit at -235 and Arizona at +195 via BetMGM. The point total or over/under sits at 54 points according to BetMGM, while DraftKings sets the line slightly higher at 54.5 points.
How do both teams match up after four weeks of play?
The Detroit Lions sit at a 2-2 record to begin the season, driven by an offense that ranks sixth in expected points added (EPA) per play and third in success rate. However, Detroit’s defense struggles to stop opponents, ranking last in opponent EPA per play and 29th in opponent success rate. Meanwhile, the Arizona Cardinals hold a 1-3 record after upsetting the Los Angeles Chargers in Week 1 before dropping three consecutive games. Similar to Detroit, Arizona features an offense in the top half of the league alongside a defense ranking in the bottom half of most metrics.
What are the key player matchups and historical trends to watch?
Detroit wide receiver Amon-Ra St. Brown remains a focal point of the offense, catching 31 passes on 46 targets for 202 yards and five touchdowns through four weeks. Historical trends show the Lions holding a 5-0-1 record in their last six meetings against the Arizona Cardinals. The under has hit in four of the last five matchups between the two franchises, contrasting with the current season trend where the over is 4-0 in Lions games.
How can fans watch the Week 5 matchup on Sunday, October 11?
The NFC showdown takes place at State Farm Stadium, with kickoff scheduled for 1:25 p.m. local time (4:25 p.m. ET). Viewers can watch the game live on FOX or stream the broadcast through Fubo. Fans should check local broadcast listings for regional coverage maps and availability.
What are the most common questions about the Detroit Lions and Arizona Cardinals game?
Where is the game being played?
The matchup takes place at State Farm Stadium, the home venue of the Arizona Cardinals.
What time does the game start?
Kickoff is scheduled for 1:25 p.m. MST, which translates to 4:25 p.m. Eastern Time.
Which TV channel is broadcasting the game?
FOX holds the broadcasting rights for the regional television coverage of the game.