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Nick Bosa Will Not Play for 49ers Against Broncos Due to Injury

Nick Bosa will not play Sunday for the San Francisco 49ers in Week 4 against the Denver Broncos, missing his second consecutive game due to a lingering calf injury suffered during practice, head coach Kyle Shanahan confirmed. Why…

Nick Bosa Will Not Play for 49ers Against Broncos Due to Injury

Nick Bosa will not play Sunday for the San Francisco 49ers in Week 4 against the Denver Broncos, missing his second consecutive game due to a lingering calf injury suffered during practice, head coach Kyle Shanahan confirmed.

Why Nick Bosa Is Missing the Broncos Game

The pass rusher missed the team’s Week 3 victory against the Arizona Cardinals and did not practice leading up to that game.

Head coach Kyle Shanahan stated that Bosa will likely miss a few weeks to recover. General manager John Lynch confirmed that the defensive end is working hard in his rehabilitation but will be out of the lineup for the contest at Levi’s Stadium in Santa Clara.

How the 49ers Defensive Line Adjusts Without Bosa

San Francisco has opted against placing Bosa on the injured reserve list, meaning he is not subject to a mandatory four-game absence and could potentially return as early as October 11 against the Seattle Seahawks, according to nohuddle.com.ar. In his absence, Ogbo Okoronkwo and Keion White will step in to anchor the defensive end position.

Nick Bosa Will Not Play for 49ers Against Broncos Due to Injury
Photo: sports.yahoo.com

The 49ers are managing additional roster challenges on the defensive front. Alfred Collins is out for the year, while C.J. West and Sam Okuayinonu are on injured reserve. Rookie Romello Height missed the previous game with a broken hand, and James Thompson Jr. is dealing with a high-ankle sprain. To bolster depth, San Francisco signed veteran edge rusher Matthew Judon to the practice squad and is preparing to open the practice window for rookie Mykel Williams.

What Lies Ahead for Both Teams in Week 4

The San Francisco 49ers enter Sunday’s contest with a 3-0 record after defeating the Arizona Cardinals 36-30. Meanwhile, the Denver Broncos arrive in California holding a 2-1 record under head coach Sean Payton, looking to capitalize on the absence of San Francisco’s pass rusher.

Kickoff is scheduled for Sunday at 16:25 Eastern Time at Levi’s Stadium. Beyond Bosa, the 49ers are monitoring the injury status of tackle Trent Williams, who has a sore neck, and wide receiver Mike Evans, both of whom carry questionable designations heading into the weekend.

Frequently Asked Questions About Nick Bosa’s Injury

When did Nick Bosa suffer his calf injury?

Bosa sustained the calf injury during a Thursday practice ahead of the team’s Week 3 game against the Arizona Cardinals.

How many games has Nick Bosa played this season?

Bosa appeared in the first two games of the season, recording seven tackles and two tackles for loss over 70 total snaps while managing a limited snap count.

Is Nick Bosa eligible to return before Week 7?

Yes. Because the 49ers chose not to place him on injured reserve, Bosa avoids the mandatory four-game absence and remains eligible to return as soon as his recovery allows.

About the author: Ibrahim Khalil - World Editor

PhD in International Relations, former UN press officer. Ibrahim has reported from 40+ countries, translating complex geopolitical shifts into clear, human‑focused narratives. “Ibrahim Khalil provides authoritative world news, from diplomacy to conflict zones, with on‑the‑ground insight.”