Nikon Software Aids University of Tokyo Research into Breast Cancer Metastasis

Nikon Corporation announced that its spatial omics visualization software played a key role in joint research led by Professor Yutaka Suzuki’s group at the Graduate School of Frontier Sciences, the University of Tokyo. Nikon also participated in the research, which focuses on understanding the mechanisms behind breast cancer metastasis.

Understanding Spatial Omics

The software technology allows researchers to visualize and analyze multiple layers of “omics” information – data relating to genes, RNA, proteins and metabolites – alongside the spatial context of biological samples. This means researchers can examine not only what molecules are present but also where they are located within a tissue sample and how their arrangement relates to the sample’s physical characteristics. This approach, known as spatial omics analysis, is crucial for studying complex diseases like cancer, where multiple factors interact across different stages and locations.

How the Software Was Used in Breast Cancer Research

In the joint research, the Nikon software was used to overlay gene expression levels and DNA methylation rates onto microscopic images of breast cancer samples. This allowed researchers to compare regions of varying malignancy. The analysis revealed several genes with significantly different expression levels depending on the cancer’s severity, suggesting that DNA methylation – a process that regulates gene expression – plays a role in these changes. Professor Suzuki’s research group at the University of Tokyo has a long history of studying full-length cDNA sequencing analysis.

About DNA Methylation

DNA methylation is an epigenetic modification, meaning it alters gene expression without changing the underlying DNA sequence. It involves adding a methyl group to a cytosine base in DNA, effectively regulating whether a gene is turned on or off. Understanding these epigenetic changes is vital for comprehending disease development and progression.

Nikon’s Commitment to Life Science Innovation

Nikon stated its commitment to contributing to improved quality of life through technologies that elucidate the causes and mechanisms of diseases. The company aims to support the development of new treatments and drugs by collaborating with academic institutions and pharmaceutical companies. Professor Suzuki is a professor at Life Science Data Research Center, Graduate School of Frontier Sciences, the University of Tokyo.

Key Takeaways

• Nikon’s spatial omics software aids in visualizing complex biological data.
• The software was used in research identifying genes linked to breast cancer malignancy.
• DNA methylation appears to play a role in regulating gene expression in breast cancer.
• Nikon is dedicated to advancing life science research through technological innovation.