Russian researchers have developed compounds from spruce extracts that slow blood clotting in laboratory tests, according to a study published in the journal Polysaccharides.
The modified spruce compounds demonstrate anticoagulant and antioxidant effects
The research team chemically altered natural polysaccharides from spruce by adding sulfate groups, which increased water solubility and biological efficiency. Laboratory tests showed these modified compounds can slow down blood clot formation, a key factor in preventing thrombosis. The same compounds also demonstrated strong antioxidant properties, neutralizing up to 96 percent of free radicals in the study.
Researchers see potential for safer treatments and biomedical applications
Scientists from the Krasnoyarsk Scientific Center, Siberian Federal University, and the Russian Ministry of Health conducted the study. They note the compounds’ natural origin and high biocompatibility with the human body could allow for lower therapeutic doses although maintaining effectiveness. Beyond medicine, the compounds are being explored for use in biomedical coatings on medical implants to prevent clot formation on device surfaces.
Preclinical results require further validation before clinical use
Researchers caution that the findings remain at the preclinical stage and are not yet ready for patient use. Turning this discovery into an available treatment will require rigorous clinical trials and extensive safety evaluations. No timeline for human testing or regulatory approval was provided in the study.
What is the source of the compounds studied?
The compounds are derived from natural polysaccharides extracted from spruce, a conifer tree widespread in many regions.
How effective are the compounds as antioxidants?
The compounds neutralized up to 96 percent of free radicals in laboratory tests, according to the study data.