Testosterone Prescriptions for Women Surge 389.6% in U.S. Over Eight Years
Testosterone prescriptions for women in the U.S. rose 389.6% between January 2018 and July 2026, according to a Truveta data analysis. Medscape reported that while randomized controlled trials and global guidelines support transdermal testosterone for HSDD, its broader application remains contentious.
Medical Guidelines Limit Testosterone Use to Specific Symptoms
Health Canada has not approved any testosterone formulations for female use, and clinical guidelines emphasize caution. Nisha Nigil Haroon, an endocrinologist and clinical associate professor at Toronto Metropolitan University, told Medscape News Canada that testosterone should only be considered for HSDD, with vaginal estrogen preferred for local symptoms. She warned against oral or pellet formulations due to dosing risks.
Study Finds Limited Benefits for Muscle Mass in Postmenopausal Women
A 26-week PAMELA trial, presented at the International Menopause Society Congress, tested female-specific testosterone on muscle mass and function in postmenopausal women. The study found no significant improvement in lower-limb muscle power or most secondary outcomes, though gains in dynamic balance and the amount of lean soft tissue in the hips and thighs were noted. The trial, which involved participants primarily of European descent and already highly active, found that while there was no effect on lower-limb muscle power, two secondary measures—dynamic balance and lean soft tissue in the hips and thighs—showed positive results. However, the study’s authors noted limitations, including the homogeneity of the participant group and the lack of long-term data.
60% of Prescriptions Target Women Aged 45–64, But Evidence Lags
Women aged 45–64 accounted for over 60% of testosterone prescriptions, with menopause, decreased libido, and hormone replacement therapy as common diagnoses. However, only HSDD causing distress is backed by medical guidelines. The study noted gaps in data, as it excluded med spas and longevity clinics, which may prescribe unregulated testosterone compounds.
Experts Urge Caution Amid Rising Use
Russell Frank, an ob/gyn with a subspeciality in menopause, told Medscape News Canada that testosterone’s benefits for menopausal women may be modest and often misreported.
Testing Confirms Testosterone Exposure Remains Within Physiologic Range
Treatment should cease if no meaningful benefit is observed within six months.
Is Testosterone Approved for Menopause in Canada?
Is testosterone approved for menopause in Canada?
No. Health Canada has not approved any testosterone formulations for female use, per Medscape.
Can testosterone improve non-sexual symptoms like fatigue?
Medical guidelines from the British Menopause Society in 2026 state that clinical trials to date have not demonstrated the beneficial effects for cognition, energy, mood and musculoskeletal health.
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