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Updated Dec. 15, 2025, 1:19 p.m. MT
The Jacksonville Jaguars and Denver Broncos play on Sunday, Dec. 21, at the Broncos’ Empower Field at Mile High in a game on the NFL Week 16 schedule.
Wich team will win the NFL Week 16 game?
Check out these NFL Week 16 picks and NFL Week 16 predictions for the game, which can be seen at 2:05 p.m.MST on FOX (stream with FUBO).
The Broncos are a 3-point favorite over the Jaguars in NFL Week 16 odds for the game, courtesy of BetMGM Sportsbook.
Denver is -160 on the moneyline, while Jacksonville is +135. the over/under (point total) is set at 46 points.
NFL Week 16 picks: Rams at Seahawks | Eagles at Commanders | Packers at Bears | buccaneers at Panthers | Bills at Browns | Chargers at Cowboys | Jets at Saints | Vikings at Giants | Chiefs at Titans | Bengals at dolphins | falcons at Cardinals | Jaguars at Broncos | Steelers at Lions | Raiders at Texans | Patriots at Ravens | 49ers at Colts | The Republic’s score predictions
Watch Jaguars at Broncos live on FUBO (free trial)
!Denver Broncos vs Jacksonville Jaguars predictions, picks, odds for NFL Week 16 game on Sunday.
Sportsnaut: Denver broncos 24, Jacksonville Jaguars 20
Matt Johnson writes: “Two of the hottest NFL teams right now go head-to-head in Week 16. A majority of the focus will rightfully be on the Denver Broncos, who have now won 11 consecutive games. However, don’t lose sight of a Jacksonville Jaguars team that is riding a five-game winning streak with a +99 point differential. This will be, by far, the best defense Trevor Lawrence has faced sence he went up against the Houston Texans. The difference: the Broncos’ star quarterback is healthy,and he’s playing behind a considerably better offensive line. Denver makes it 12 straight wins and secures the AFC West crown.”
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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