President Launches “Genesis Mission” to Accelerate AI-Driven Scientific Discovery

By the authority vested in me as President by the Constitution adn the laws of the United States of America, it is hereby ordered:

Section 1. Purpose. from the founding of our Republic,scientific discovery and technological innovation have driven American progress and prosperity. Today, America is in a race for global technology dominance in the advancement of artificial intelligence (AI), an crucial frontier of scientific discovery and economic growth. To that end, my Administration has taken a number of actions to win that race, including issuing multiple Executive Orders and implementing America’s AI Action Plan, which recognizes the need to invest in AI-enabled science to accelerate scientific advancement. In this pivotal moment, the challenges we face require a historic national effort, comparable in urgency and ambition to the Manhattan Project that was instrumental to our victory in World War II and was a critical basis for the foundation of the Department of Energy (DOE) and its national laboratories.

This order launches the “Genesis Mission” as a dedicated, coordinated national effort to unleash a new age of AI‑accelerated innovation and discovery that can solve the most challenging problems of this century. The Genesis Mission will build an integrated AI platform to harness Federal scientific datasets – the world’s largest collection of such datasets, developed over decades of Federal investments – to train scientific foundation models and create AI agents to test new hypotheses, automate research workflows, and accelerate scientific breakthroughs.The genesis Mission will bring together our Nation’s research and development resources – combining the efforts of brilliant American scientists, including those at our national laboratories, with pioneering American businesses; world-renowned universities; and existing research infrastructure, data repositories, production plants, and national security sites – to achieve dramatic acceleration in AI development and utilization. We will harness for the benefit of our Nation the revolution underway in computing,and build on decades of innovation in semiconductors and high-performance computing. The genesis Mission will dramatically accelerate scientific discovery, strengthen national security, secure energy dominance, enhance workforce productivity, and multiply the return on taxpayer investment into research and development, thereby furthering America’s technological dominance and global strategic leadership.

Sec. 2. Establishment of the Genesis Mission. (a) There is hereby established the Genesis Mission (Mission), a national effort to accelerate the application of AI for transformative scientific discovery focused on pressing national challenges.

(b) The Secretary of Energy (Secretary) shall be responsible for implementing the Mission within DOE, consistent with the provisions of this order, including, as appropriate and authorized by law, setting priorities and ensuring that all DOE resources used for elements of the Mission are integrated into a secure, unified platform. the Secretary may designate a senior political appointee to oversee day-to-day operations of the Mission.

(c) The Assistant to the President for Science and Technology (APST) shall provide general leadership of the Mission, including coordination of participating executive departments and agencies (agencies) through the National Science and Technology Council (NSTC) and the issuance of guidance to ensure that the Mission is aligned with national objectives.

Sec. 3. Operation of the american Science and Security Platform. (a) The Secretary shall establish and operate the American Science and Security Platform (Platform) to serve as the infrastructure for the Mission with the purpose of providing, in an integrated manner and to the maximum extent practicable and consistent with law:

(i) high-performance computing resources, including DOE national laboratory supercomputers and secure cloud-based AI computing environments, ca

AI Mission: interagency Coordination and Data Integration

This document outlines key provisions for interagency coordination and data integration related to an AI-driven scientific mission. It focuses on the roles of the APST (Artificial Intelligence Policy Steering Team) and the NSTC (National Science and Technology Council) in aligning federal efforts and engaging external partners.

Sec. 5. Interagency Coordination and External Engagement

The APST, working through the NSTC, will lead efforts to coordinate agencies involved in the AI mission.This coordination will be supported by the Federal Chief Data Officer Council and the Chief AI Officer Council.

Key Coordination Activities:

• Alignment of Programs: Participating agencies will align their AI-related programs, datasets, and research with the mission’s objectives, avoiding duplication and promoting interoperability, as permitted by law.
• Data Source Identification: The APST will identify data sources that can support the mission’s goals.
• Data Integration Plan: A plan will be developed, in collaboration with agencies, to integrate relevant data and infrastructure into the mission. This includes implementing robust, risk-based security measures and cybersecurity best practices.
• Incentivizing Private Sector Participation: Coordinated funding opportunities and prize competitions will be launched to encourage private-sector involvement in AI-driven scientific research aligned with mission objectives.
• research Funding Coordination: Mechanisms will be established to coordinate research and development funding and experimental resources across participating agencies, ensuring effective participation.

The APST will also work with agencies to establish competitive programs for research fellowships,internships,and apprenticeships. These programs will focus on applying AI to scientific domains identified as national challenges within the mission. Participants will have opportunities for placement at DOE national laboratories and other participating institutions.