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Celebrities have been striving for health in 2025, with many dropping critically important amounts of weight – in many cases with the help of GLP-1 medications like Ozempic.
below are four A-list stars who shared their weight-loss journeys this year, with or without the help of prescription drugs.
No.1: Oprah Winfrey
Long-time talk show host oprah Winfrey was recently featured in an exclusive interview with People magazine,during which she discussed her weight loss and her new book,”Enough: Your Health,Your Weight and What It’s Like to Be Free.”
OPRAH WINFREY ADMITS SHE DRANK 17 SHOTS OF TEQUILA IN ONE NIGHT BEFORE GIVING UP ALCOHOL DUE TO GLP-1
Winfrey, 71, began taking a GLP-1 medication in 2023 but attempted to quit just six months in to see if she could lose weight without it. Regardless of her diet and exercise routines, the media mogul said she still gained back 20 pounds after stopping the drug.
Celebrities Who Revealed Weight Loss in 2025: Oprah, Amy Schumer and More
Several celebrities have publicly shared their weight loss journeys in 2025, sparking conversations about health, wellness and the evolving landscape of weight management. Here’s a look at some of the most prominent transformations:
No.1: Oprah Winfrey
Media mogul Oprah Winfrey revealed in December 2025 that she had been using weight loss medication, joining a growing number of public figures who have embraced the option.
“For me, it’s about freeing myself from the years of yo-yo dieting,” winfrey told People magazine. “I’ve tried everything, and this is the first time I feel like I have a sustainable path forward.”
Regardless of GLP-1 access or tolerance, Winfrey encouraged those struggling with obesity that it is indeed “not your fault.”
“I want people to stop blaming [themselves] for genes and an surroundings [they] can’t control,” she said. “I want people to have the facts, whatever you choose to do with it, whether you get the medications, or whether you want to keep dieting.”
No. 2: Amy Schumer
Comedian Amy Schumer dropped 50 pounds after being diagnosed with Cushing’s syndrome, a hormonal disorder that can cause extreme swelling, fatigue and potentially fatal complications.
OLDER AMERICANS ARE QUITTING GLP-1 WEIGHT-LOSS DRUGS FOR 4 KEY REASONS
Schumer’s change sparked conversation online, to which she responded in a now-deleted Instagram post that shut down speculation about cosmetic enhancements.
“I didn’t lose 30 lbs – I lost 50,” she emphasized on social media, adding that she does not get Botox or filler.
No. 3: Meghan Trainor
Singer Meghan Trainor has been open about her weight loss journey, attributing it to a combination of lifestyle changes and, reportedly, the use of a GLP-1 medication.
Trainor has documented her fitness progress on social media, sharing workout routines and healthy meal choices with her followers. She has also spoken candidly about the challenges of navigating body image and societal expectations.
Meghan Trainor and Lizzo: Celebrities Opening up About Weight Loss journeys and GLP-1 Medications
Meghan Trainor is addressing the online criticism surrounding her recent weight loss. the singer, who debuted a noticeably slimmer physique at the Baby2Baby Gala in november, shared her frustrations with the negativity she’s received.
“I feel great, and that’s when people attack me,” she said, noting that the criticism is only getting “louder” and “meaner.” Despite the online noise, trainor emphasized that she’s focused on her well-being.
“I’m taking care of myself,” she reiterated.”I have to find a way to not be affected by that.”
GLP-1 WEIGHT-LOSS MEDICATIONS LINKED TO IMPROVED CANCER SURVIVAL IN CERTAIN PATIENTS
The singer’s health journey began by eliminating gluten and dairy from her diet after finding out that she had a “leaky gut.” The artist also got serious about strength training.
Trainor’s own fitness trainer, Bella Maher of Malibu Bodies, posted before-and-after photos of the pop star on Instagram, revealing how hard she worked before introducing a GLP-1 drug.
“Watching her transform from the inside out has been one of the most meaningful parts of my work,” the caption reads. “She did so much of this on her own before ever introducing a GLP-1, and even after starting it, the medication was simply a support, not the reason for her results. GLP-1s can be a powerful tool, but they’re certainly not a transformation plan. SHE is the reason this worked.”
No. 4: Lizzo
Singer and musician Lizzo stepped out this year with a slimmer figure, as the public speculated about her GLP-1 use.
During a discussion about Ozempic on Trisha Paytas’ “Just Trish” podcast in June, the musician shared that she had “tried everything” for weight loss.
“Ozempic works because you eat less food,” she said.”It makes you feel f