Eric Dane, ‘Grey’s Anatomy’ Star, Dies at 53 After ALS Battle

Eric Dane, best known for his role as Dr. Mark Sloan on the television series “Grey’s Anatomy,” has died at the age of 53 following a battle with amyotrophic lateral sclerosis (ALS). His family announced his passing on Thursday, February 20, 2026.

ALS Diagnosis and Advocacy

Dane publicly revealed his diagnosis of ALS in April 2025 [CBS News]. Throughout his fight with the disease, he became a passionate advocate for raising awareness and funding research into ALS, also known as Lou Gehrig’s disease [Everyday Health].

A Prolific Career

Beyond “Grey’s Anatomy,” Dane enjoyed a diverse and extensive acting career spanning several decades. He appeared in roles on television shows including “Euphoria” and “Charmed,” and in films such as “X-Men: Last Stand” (2006) and “Burlesque” (2010) [CBS News], [BBC News].

Family and Legacy

Dane is survived by his wife, actress Rebecca Gayheart, and their two daughters, Billie and Georgia. His family shared that he spent his final days surrounded by loved ones [CBS News]. They requested privacy during this difficult time.

Understanding ALS

ALS is a progressive neurodegenerative disease that affects the nervous system, impacting the brain and spinal cord [CBS News]. According to the ALS Association, approximately 1 in 300 Americans are affected by the disease. The life expectancy following an ALS diagnosis is typically three to five years [CBS News].

Tributes from Colleagues

Fellow actors have begun to share tributes to Dane, remembering him as a talented and joyful colleague [BBC News]. Patrick Dempsey, who co-starred with Dane on “Grey’s Anatomy,” described him as “a joy to work with” [BBC News].