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Pete Prisco’s Week 6 NFL Picks, Predictions and Odds

Pete Prisco Rebounds with 10-4-1 Record in Week 5 NFL Predictions CBS Sports analyst Pete Prisco bounced back from a difficult Week 4 by posting a 10-4-1 straight-up record and a 9-6-1 mark against the spread during Week…

Pete Prisco's Week 6 NFL Picks, Predictions and Odds

Pete Prisco Rebounds with 10-4-1 Record in Week 5 NFL Predictions

CBS Sports analyst Pete Prisco bounced back from a difficult Week 4 by posting a 10-4-1 straight-up record and a 9-6-1 mark against the spread during Week 5 of the NFL season, cbssports.com reported. Prisco’s overall season totals stand at 48-30-1 straight up and 34-43-2 against the spread. Entering Week 6, Prisco aims to continue building momentum while slowly climbing back above the .500 mark against the spread following a challenging Week 3.

Seattle Seahawks at Denver Broncos Matchup Analysis

The Seattle Seahawks hit the road on a short week to face the Denver Broncos on Thursday night following a tough loss to the San Francisco 49ers. CBS Sports reported that Denver’s offense continues to struggle despite Sean Payton taking over play-calling duties. Quarterback Bo Nix faces a difficult test against a strong Seattle defense. Prisco picks the Seahawks to secure a 23-17 road victory.

Game Matchup Prisco’s Pick
Seattle Seahawks at Denver Broncos Seahawks 23, Broncos 17
Houston Texans at Jacksonville Jaguars Jaguars 24, Texans 20
Chicago Bears at Atlanta Falcons Falcons 27, Bears 21
Baltimore Ravens at Cleveland Browns Ravens 24, Browns 13

International Slate and Divisional Showdowns in Week 6

The Houston Texans travel to London to face the Jacksonville Jaguars on Sunday morning at 9:30 a.m. ET. Fantasy Nerds noted that the Jaguars have spent two weeks in London, whereas the Texans traveled across the Atlantic this week. Despite a sloppy performance last week, Prisco predicts the Jaguars will secure a 24-20 victory to maintain their divisional positioning. In other early window action, the Chicago Bears visit the Atlanta Falcons. The Falcons expect quarterback Michael Penix Jr. to play after suffering an injury against the Baltimore Ravens, and Prisco backs Atlanta to exploit a Bears defense that surrendered significant yardage to the Green Bay Packers, forecasting a 27-21 final score.

The Baltimore Ravens travel to face the Cleveland Browns with uncertainty surrounding quarterback Lamar Jackson’s status due to an ankle injury. Prisco anticipates that the Ravens defense will contain the Browns offense regardless of Jackson’s availability, projecting a 24-13 Ravens win. Meanwhile, the winless Tennessee Titans visit the Indianapolis Colts. The Colts lean on an improved defense and running back Jonathan Taylor to secure a 28-17 victory, according to CBS Sports projections.

Conference Clashes and Playoff Contenders

The New England Patriots host the New York Jets aiming for their third consecutive victory under quarterback Drake Maye. Prisco picks the Patriots to win 28-13 against a Jets defense that recorded eight sacks against Cleveland last week but faces a stiffer offensive challenge. In another matchup, the New York Giants host the New Orleans Saints, who have dropped three straight games. Prisco expects a defensive struggle resulting in a narrow 19-16 Giants victory.

The Philadelphia Eagles return from a London loss to face the Carolina Panthers, who are coming off a bye week. Prisco notes that mounting injuries create a sense of desperation for Philadelphia, but expects their defense to secure a 23-20 win. In Tampa Bay, the Buccaneers host the Pittsburgh Steelers after leaning on running back Bucky Irving to defeat the Dallas Cowboys. Prisco predicts the Buccaneers will limit Aaron Rodgers and claim a 26-21 victory.

Prime-Time Schedules and Closing Slate

The Los Angeles Rams host the Arizona Cardinals looking to improve their 2-3 record. Prisco expects quarterback Matthew Stafford to lead a dominant offensive showing in a 35-20 Rams win. The undefeated Kansas City Chiefs return from a bye to host the winless Los Angeles Chargers, with Prisco favoring the Chiefs 28-21 due to head coach Andy Reid’s historical success following bye weeks.

Kyle Long and Pete Prisco preview Patriots vs Seahawks in Super Bowl LX 🏆 | Picks to Win & Best Bets

The Buffalo Bills stay on the West Coast after an overtime victory against the Rams to face the Las Vegas Raiders on a short week. Prisco projects a 35-21 Bills victory driven by their high-powered offense. In Sunday night action, the Green Bay Packers host the Dallas Cowboys following a dominant win over Chicago. Prisco forecasts a 31-27 Packers victory as quarterback Jordan Love targets a vulnerable Dallas secondary. Finally, the San Francisco 49ers host the Washington Commanders on Monday night. Prisco picks the 49ers to win 30-21, as quarterback Brock Purdy continues his strong campaign as an MVP candidate.

Frequently Asked Questions

What is Pete Prisco’s overall record heading into Week 6?

Prisco holds a 48-30-1 straight-up record and a 34-43-2 mark against the spread through the first five weeks of the NFL season.

Where is the Week 6 international game taking place?

The Houston Texans and Jacksonville Jaguars play in London on Sunday at 9:30 a.m. ET, broadcast on NFL Network.

How many consecutive games have the New England Patriots won entering their matchup against the Jets?

The Patriots enter the game on a two-game winning streak following consecutive victories sparked by quarterback Drake Maye.

NFL *Week 6* Picks & Predictions | 2026
About the author: Javier Moreno - Sports Editor

Former sideline reporter and FIFA‑accredited correspondent. Javier covers football, boxing, and Olympic sports, blending analytics with athlete‑focused storytelling. Javier Moreno offers in‑depth sports coverage, live analysis, and exclusive interviews from global arenas.