Preclinical

Researchers are identifying new approaches to BET protein inhibitors, targeting a class of epigenetic regulators that have historically proven difficult to drug effectively in solid tumors. By shifting from traditional …

First-in-Class Experimental CAR T-Cell Therapy Shows Promise Against Solid Tumors, Study Finds A first-in-class experimental CAR T-cell therapy has demonstrated preliminary success in targeting solid tumors, according to a 2023 …

New research indicates that combining targeted therapies with immunotherapy significantly improves clinical outcomes for patients with advanced, treatment-resistant melanoma. According to findings published in the Journal of Clinical Oncology, patients …

Chronic stress linked to tumor immune evasion via gut microbiome changes, study finds Chronic stress may enable tumors to evade immune detection by altering gut microbiome composition, according to a …

Three Cognitive Trajectories Identified in Preclinical Alzheimer’s Disease: What They Mean for Early Intervention By Dr. Natalie Singh, Health Editor | April 28, 2026 Alzheimer’s disease doesn’t develop overnight. Long …

Red Blood Cells Engineered for Targeted Drug Delivery and Imaging Show Promise in Preclinical Trials Researchers have developed a novel method to tag red blood cells (RBCs) with long-lasting chemical …

Weight Loss Drug Semaglutide Fails to Leisurely Alzheimer’s Progression Despite initial optimism stemming from observational studies and biomarker changes, recent Phase 3 clinical trials published in The Lancet have demonstrated …

Gut Microbiome May Predict Response to GLP-1 Weight Loss Medications New research highlights the growing understanding of how the gut microbiome influences the effectiveness of glucagon-like peptide-1 receptor agonists (GLP-1 …

Cancer Interception: New Approach Shows Promise in Pancreatic Cancer Models A new preclinical study in mice demonstrates that eliminating precancerous cells in the pancreas before they develop into tumors is …

Mayo Clinic Study: Drug Combination Shows Promise in Combating Diabetic Kidney Disease Researchers at the Mayo Clinic have identified a combination therapy—the cancer drug dasatinib and the naturally occurring substance …