Can Diet Protect Against Alzheimer’s? Researchers Investigate the Role of Polyphenols
As Alzheimer’s disease and dementia become increasingly prevalent public health challenges, researchers are exploring whether dietary interventions could offer a protective effect. A new study, MAEVE, led by researchers at Ulster University and collaborating institutions, is investigating the potential of plant-based compounds called polyphenols to support brain health and mitigate the risk of Alzheimer’s disease.
The Rising Incidence of Dementia and Alzheimer’s Disease
Dementia is characterized by a progressive decline in cognitive function and memory. Alzheimer’s disease is the most common cause of dementia, accounting for 60 to 70 percent of cases. In Ireland, an estimated 64,000 people are currently living with dementia [1], with projections indicating a doubling of cases to 150,000 by 2045.
The MAEVE Study: Investigating Polyphenols and Brain Health
Researchers, including Brian Og Murphy and Professor Chris Gill at Ulster University, are investigating whether nutritional approaches, specifically through diet or supplementation, can influence the biological pathways linked to brain health and protect against Alzheimer’s disease. [2] The study focuses on polyphenols – compounds found in foods like berries, coffee beans, and cocoa – and how they may support brain health in individuals at increased risk of Alzheimer’s, including those with a family history or specific genetic variants.
How Polyphenols May Protect the Brain
The investigation aims to understand how polyphenols influence the body’s pathways through the gut, potentially protecting the brain against Alzheimer’s disease. Researchers hypothesize that these compounds may impact the physiology of bile acids, which could play a role in cognitive health. [3] This area of research is still emerging, and the precise mechanisms are under investigation.
The MAEVE Trial: A Multi-Center Approach
The MAEVE study, a five-year, multi-center trial funded through the Tripartite US-Ireland Research & Development Partnership Program, will investigate the impact of dietary polyphenol supplements on 300 older adults at risk for Alzheimer’s disease. [4] Researchers will analyze cognitive functioning, brain structure and function, the microbiome, inflammatory markers, and Alzheimer’s disease-specific plasma markers to understand the effects of polyphenols.
Incorporating Polyphenols into Your Diet
While the MAEVE study focuses on supplements, consuming polyphenol-rich foods may also offer benefits. Research suggests that consuming two portions of berries (around 120g), less processed coffee beans, and high percentages of dark chocolate may have protective effects.
Participating in the MAEVE Study
Individuals in Donegal and Ulster interested in participating in the MAEVE study can contact the researchers at B.Murphy2@ulster.ac.uk and C.Gill@ulster.ac.uk for more information.