The Philadelphia Eagles and Tampa Bay Buccaneers play on Sunday,Sept. 28, at the Buccaneers’ Raymond James Stadium in a game on the NFL Week 4 schedule.
NFL Week 4: Picks, Predictions and Odds for Every Game
NFL week 4 is here, bringing a fresh slate of matchups as teams battle for early season positioning. Here’s a breakdown of picks, predictions, and odds for every game on the schedule, as of September 22, 2025. (All odds via BetMGM)
Thursday, September 19
* Chicago Bears at Jacksonville Jaguars: Jaguars -7.5. Pick: Jaguars. Jacksonville’s offense is clicking, and Chicago is still finding its footing.
Sunday, September 22
* Washington Commanders at Atlanta Falcons: Falcons -3. Pick: Falcons.Atlanta’s run game will be too much for Washington to handle.
* New Orleans Saints at buffalo Bills: Bills -7. Pick: Bills.Buffalo bounces back at home after a tough loss.
* Cleveland Browns at Detroit Lions: Lions -2.5. Pick: Lions. Detroit’s offense will be the difference-maker in a close contest.
* Tennessee Titans at Houston Texans: Texans -3. Pick: Texans. C.J. Stroud continues to impress as Houston secures a divisional win.
* Carolina Panthers at New England Patriots: Patriots -2.5. Pick: Patriots. New England needs a win and will deliver at home.
* Los Angeles Chargers at New York Giants: Chargers -6. Pick: Chargers. Justin Herbert and the Chargers’ passing attack will overwhelm the Giants.
* Philadelphia Eagles at Tampa Bay Buccaneers: Eagles -7. Pick: Eagles. Philadelphia’s dominant defense will stifle Tampa Bay’s offense.
* Pittsburgh Steelers at Las Vegas Raiders: Steelers -2.5. Pick: Steelers. Pittsburgh’s defense will be the deciding factor in a low-scoring affair.
* Denver Broncos at Green Bay Packers: Packers -3. Pick: Packers. Jordan Love and the packers’ offense find their rhythm against a struggling Broncos defense.
* Miami Dolphins at Seattle Seahawks: Dolphins -3.5. Pick: dolphins. Miami’s speed will be too much for Seattle to contain.
* Cincinnati Bengals at Baltimore Ravens: Ravens -3. Pick: Ravens. A tough divisional matchup, but Baltimore’s defense gives them the edge.
* Kansas City Chiefs at New York Jets: Chiefs -7.5. Pick: Chiefs.Patrick Mahomes is simply too much for the Jets to overcome, even with a motivated defense.
Monday, September 23
* Dallas Cowboys at Arizona Cardinals: Cowboys -7. Pick: Cowboys. Dallas’s defense will dominate, leading to a comfortable victory.
* Minnesota Vikings at Los Angeles Rams: Vikings -3. Pick: Vikings. Minnesota’s offense finds success against a rebuilding Rams team.
Disclaimer: These are predictions based on current information and analysis. Odds are subject to change. Please gamble responsibly.
NFL Week 4: Picks, Predictions and Odds for Eagles vs. Buccaneers and More
Three undefeated teams remain in the NFC. The eagles and Buccaneers are two of them. While the Eagles are a 3-point favorite, there’s a feeling that Tampa Bay will play inspired defense at home and spring the upset with a late field goal.
Bookies.com: Bet the Eagles to cover vs Buccaneers.
Bill Speros writes: “Tampa Tom makes his homecoming inside the FOX booth to add some juice to our NFL Week 4 Best Bets. He’ll call a game featuring 2 undefeated teams that have met in the postseason twice in the past 4 years. The Bucs won both. Tampa Bay and Philly could well meet again this postseason. The Eagles stunned the Rams and those who bet on LA by erasing a 19-point deficit in their 33-27 win Sunday. The Eagles nabbed the 4.5-point cover as Jordan Davis blocked a field goal attempt that would have won it for LA. He grabbed the ball and rumbled 61 yards for the TD.”
For more picks and predictions on pivotal games this week, see The Republic’s score predictions.
You can also find predictions for Bengals at Broncos here.
Watch Eagles at Buccaneers live on FUBO (free trial).
Buccaneers 31, Eagles 24
Matt Johnson writes: “The Tampa Bay Buccaneers are expected to get left tackle Tristan Wirfs and wide receiver Chris Godwin back in Week 4. it’s suboptimal timing for the Philadelphia Eagles. Not only can Tampa Bay shut down the run game (84 rushing yards per game and 3.6 yards per carry allowed), but they also have the receiver trio to exploit this Eagles secondary. Jalen Hurts and A.J. Brown will help make this one of the best games on the NFL schedule this week, but Tampa Bay will look like the better team Sunday and come out with the victory.”
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