Eric Dane, ‘Grey’s Anatomy’ and ‘Euphoria’ Star, Dies at 53 After ALS Battle

Eric Dane, celebrated for his roles as Dr. Mark Sloan (“McSteamy”) on Grey’s Anatomy and Cal Jacobs on Euphoria, has died at the age of 53 following a battle with amyotrophic lateral sclerosis (ALS). The news was confirmed on Thursday, February 19, 2026, with updates continuing on February 20, 2026.

ALS Diagnosis and Recent Activity

Dane publicly announced his ALS diagnosis in April 2025 [CBS News]. Despite the debilitating effects of the disease, he remained committed to his work and advocacy. He was scheduled to be honored with the Dean and Kathleen Rasmussen Advocate of the Year Award at an ALS Network gala in January 2026, but had to withdraw due to the physical challenges posed by his condition [USA Today]. He also missed a scheduled appearance at the 2025 Emmy Awards alongside former Grey’s Anatomy costar Jesse Williams [USA Today].

Career Highlights

Eric Dane first gained widespread recognition in 2006 as Dr. Mark Sloan, affectionately known as “McSteamy,” on Grey’s Anatomy [New York Times]. His portrayal of the charismatic plastic surgeon became a fan favorite. More recently, he starred as Cal Jacobs, a complex and troubled father, in the HBO series Euphoria [BBC News]. Dane’s career spanned decades, with roles in films such as X-Men: Last Stand (2006) and Burlesque (2010), as well as television shows including Charmed and The Last Ship [CBS News].

Family and Legacy

Dane is survived by his wife, actress Rebecca Gayheart, and their two daughters, Billie and Georgia. His representative, Melissa Bank, stated that he spent his final days surrounded by loved ones [USA Today]. Throughout his battle with ALS, Dane dedicated himself to raising awareness and supporting research efforts to combat the disease [USA Today]. His family has requested privacy during this difficult time.

Understanding ALS

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord [CBS News]. The condition causes loss of muscle control, eventually leading to paralysis. The cause of ALS is currently unknown, and there is no cure. According to the ALS Association, approximately 1 in 300 Americans are affected by the disease [CBS News]. Life expectancy following diagnosis is typically three to five years [CBS News].