Eric Dane, ‘Grey’s Anatomy’ and ‘Euphoria’ Star, Dies at 53 After ALS Battle

Eric Dane, known for his roles as Dr. Mark Sloan on “Grey’s Anatomy” and Cal Jacobs in the HBO series “Euphoria,” died Thursday, February 19, 2026, at the age of 53, following a battle with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease.

ALS Diagnosis and Advocacy

Dane publicly disclosed his ALS diagnosis in April 2025. His family announced his passing, stating he spent his final days surrounded by loved ones, including his wife and two daughters, Billie and Georgia. Throughout his journey with ALS, Dane became a passionate advocate for awareness and research, determined to make a difference for others facing the same fight.

Early Symptoms and Diagnosis

Dane first noticed symptoms of weakness in his right hand approximately a year and a half before his diagnosis, around late 2023 or early 2024. Initially attributing the weakness to overuse from texting, he sought medical attention when the symptoms progressed. After consulting multiple neurologists over nine months, he received an ALS diagnosis.

Progression of the Disease

By June 2025, Dane had lost function in his right arm. He shared that he could perceive the strength deteriorating in his left arm as well. His speech also began to change, becoming slower and slurred, as evidenced in a September 2025 video shared on social media where he emphasized the importance of finding a cure for ALS.

What is ALS?

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. According to the Centers for Disease Control and Prevention, ALS causes a loss of muscle control and worsens over time. Symptoms can include muscle weakness, cramps, stiffness, difficulty swallowing and speaking, and eventually, the loss of ability to walk, stand, breathe, and speak. The cause of ALS is largely unknown, with only a small number of cases being inherited.

Life expectancy after an ALS diagnosis is typically between three and five years. There is currently no cure, but treatments can help manage symptoms and potentially slow the disease’s progression.

Career Highlights

Eric Dane gained widespread recognition for his role as Dr. Mark Sloan on “Grey’s Anatomy,” appearing from 2006 to 2012. His character was fatally injured in a plane crash at the end of the eighth season. He also starred as Cal Jacobs in the HBO series “Euphoria.”

Final Messages

In his final interview, Dane shared four messages for his daughters: “Live in the present,” “Fall in love,” “Identify your people,” and “Fight with every ounce of your being.”