What are the Symptoms of Hyper-IgM Syndrome?

The most common sign of hyper-IgM syndrome is getting infections ofen. These can include:

• Bacterial infections, like sinus infections and ear infections
• Serious respiratory infections, like pneumonia
• Unusual bacterial, fungal, parasitic, and viral infections because the immune system is weak

Frequent or ongoing diarrhea is also common in people with hyper-IgM syndrome.

What Causes Hyper-igm syndrome?

Hyper-IgM syndromes happen because of problems with your B cells. Usually, changes in your DNA that you’re born with cause these problems. These changes stop your immune cells from switching classes – changing the type of antibody they make from IgM antibodies to other types.You get these changes from one or both of your parents.

When you first get an infection from a specific germ, a type of white blood cell called a B cell makes IgM antibodies.