Luton man’s brain tumour shrinks by half in therapy trial

by Dr Natalie Singh - Health Editor
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Brain Tumour Shrinks by Half After New Radioactive Therapy

University College London Hospitals NHS Foundation Trust Paul Read stood outside to the left of his wife Pauline. Behind the pair is lots of greenery from plants, trees and grass. Paul and Pauline are stood close together and both face the camera to smile. Paul wears a dark grey jacket with a red shirt and has short white hair. Pauline is wearing a cream denim jacket with a white blouse underneath. She has short white hair with a side fringe coming over her forehead and square framed glasses.
University College London Hospitals NHS Foundation Trust

Paul Read was the first patient recruited in a new therapy trial for treating brain tumours

A man’s brain tumour has shrunk by half in a matter of weeks thanks to a new radioactive therapy.

The therapy, at University College London Hospitals NHS Foundation Trust (UCLH), involved injecting low levels of radioactivity directly into the tumour to kill off cancer cells.

The doctor who designed the trial said the results were “remarkable for somebody whose tumour is so aggressive”.

Surgeons first removed as much tumour as possible before implanting a small medical device, called an Ommaya reservoir, under the scalp.

The drug ATT001, which is given weekly for four to six weeks, is potent over short distances, causing lethal damage to cancer cells while sparing healthy tissue.

Luton man's brain tumour shrinks by half in therapy trial
University College London Hospitals NHS Foundation Trust Side profile of Paul looking to the right. His scar from brain tumour surgery can we seen clearly and is a thin dark purple line in an almost crescent shape. It begins just above his right eyebrow, travels back to his hair, curving down to reach his ear. The scar stops just in front of the middle of Paul's ear. His background is blurred but looks to be a medical setting with plain white walls and a computer.
University College London Hospitals NHS Foundation Trust

A doctor said Mr Read’s results were remarkable given how tumour was so aggressive

The trial was designed by UCLH consultant medical oncologist and chief investigator Dr Paul Mulholland.

Because it’s to the tumour cells, it’s very at killing them.

We’ve just through [Paul’s scan results with him and his treatment scan shows a in the tumour, which is really quite for somebody whose tumour is so aggressive.

Dr said, hoped to increase the dose of and number of patients.

Paul had surgery shortly after his to remove as much of the tumour as possible, followed by and after that.

In July, doctors found the tumour was and he was offered a place on the new CITADEL-123 trial at UCLH.

“I was fully expecting the tumour to due to its nature. I know the is great and I was happy to explore anything else.

“It will be wonderful if this treatment me and if it doesn’t… it may benefit someone down the line.

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