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## New Process Converts Glucose Directly into Tagatose, Boosting Sustainable Sweetener Production
A novel process utilizing a galactose-1-phosphate-specific phosphatase, extracted from slime mold, offers a new pathway for converting glucose directly into tagatose. This enzymatic conversion bypasses the traditional reliance on galactose derived from lactose. The study, published in Cell Reports Physical Science, conducted in collaboration with Manus Bio and Kcat Enzymatic, demonstrates that this reverse metabolic pathway allows tagatose to be obtained directly from glucose, eliminating the need for lactose-derived galactose.
Impact on Efficiency
The research highlights: “This strategy eliminates dependence on galactose derived from lactose and provides a framework for scalable glucose-based biosynthesis of tagatose and other galactose-derived molecules, supporting the sustainable production of rare sugars.” Laboratory trials have shown significant improvements in yield, achieving 95%, considerably higher than previous methods which typically ranged from 40% to 77%. Researchers achieved up to 10.5 grams per liter of galactose from 30 grams per liter of glucose, and over one gram per liter of tagatose.
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