Eric Dane, ‘Grey’s Anatomy’ Star, Dies at 53 Following ALS Battle

Eric Dane, best known for his role as Dr. Mark Sloan on the television series “Grey’s Anatomy,” has died at the age of 53 after a battle with amyotrophic lateral sclerosis (ALS). His family announced his death on Thursday, February 19, 2026.

ALS Diagnosis and Advocacy

Dane publicly announced his diagnosis of ALS in April 2025 [CBS News]. Throughout his battle with the disease, he became a passionate advocate for awareness and research, determined to make a difference for others facing the same challenges [CBS News], [TODAY].

Career Highlights

Dane first gained prominence for his role as Dr. Mark Sloan, nicknamed “McSteamy,” on “Grey’s Anatomy,” appearing in 139 episodes between 2006 and 2021 [BBC News]. He also starred as Cal Jacobs in the HBO drama series “Euphoria” [BBC News], [TODAY]. His career spanned several decades, with early television appearances dating back to 1991, including a role in “Saved by the Bell” [BBC News]. He also appeared in films such as “Marley & Me,” “Valentine’s Day,” and “Burlesque” [CBS News].

Family and Legacy

Eric Dane is survived by his wife, actress Rebecca Gayheart and their two daughters, Billie and Georgia [CBS News], [TODAY]. His family stated he spent his final days surrounded by loved ones [CBS News], [TODAY].

Understanding ALS

ALS, also known as Lou Gehrig’s disease, is a progressive nervous system disease that affects nerve cells in the brain and spinal cord, leading to loss of muscle control [CBS News], [TODAY]. The cause of ALS is unknown, and there is currently no cure. According to the ALS Association, approximately 30,000 people in the United States are affected by the disease at any given time [TODAY]. Life expectancy following diagnosis is typically three to five years [CBS News].