Eric Dane, “Grey’s Anatomy” Star, Dies at 53 After ALS Diagnosis

Eric Dane, best known for his role as Dr. Mark Sloan on the hit medical drama “Grey’s Anatomy,” has died at the age of 53 following a battle with amyotrophic lateral sclerosis (ALS), his family announced on February 19, 2026. [CBS News]

ALS Diagnosis and Advocacy

Dane publicly revealed his diagnosis of ALS, as well known as Lou Gehrig’s disease, in April 2025. [People] Throughout his illness, he became a passionate advocate for raising awareness and funding research for the disease. [CBS News]

A Prolific Career

Born on November 9, 1972, in San Francisco, California, Dane began his acting career in the early 1990s, with early roles in television series such as “Saved by the Bell” and “The Wonder Years.” [Wikipedia] He gained wider recognition for his recurring role as Jason Dean on “Charmed.” [Wikipedia]

His breakthrough role came with “Grey’s Anatomy” (2006–2012; 2021), where he portrayed the charismatic Dr. Mark Sloan, earning him the nickname “Dr. McSteamy.” [Wikipedia] Dane also appeared in several films, including “X-Men: The Last Stand” (2006), “Marley & Me” (2008), “Valentine’s Day” (2010), “Burlesque” (2010), and “Bad Boys: Ride or Die” (2024). [Wikipedia]

More recently, he starred as Captain Tom Chandler in “The Last Ship,” Cal Jacobs in “Euphoria,” and FBI Special Agent Nathan Blythe in “Countdown.” [Wikipedia]

Family and Legacy

Eric Dane is survived by his wife, actress Rebecca Gayheart, and their two daughters, Billie, and Georgia. [CBS News] His family stated that he spent his final days surrounded by loved ones. [CBS News] They have requested privacy during this difficult time. [CBS News]

Dane’s colleagues and fans have expressed their grief and admiration for his talent and courage. [BBC News]

Understanding ALS

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord, leading to muscle weakness, paralysis, and eventually, death. [CBS News] The cause of ALS is unknown, and there is currently no cure. [CBS News] According to the ALS Association, about 1 in 300 Americans are affected by the disease. [CBS News] The life expectancy following diagnosis is typically three to five years. [CBS News]