Eric Dane, ‘Grey’s Anatomy’ and ‘Euphoria’ Star, Dies at 53 After ALS Battle

Eric Dane, the celebrated actor best known for his roles in “Grey’s Anatomy” and “Euphoria,” has died at the age of 53 following a courageous battle with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. His death was announced Thursday by his representatives.

ALS Diagnosis and Advocacy

Dane publicly revealed his diagnosis of ALS in April 2025 [CBS News]. Throughout his journey with the disease, he became a passionate advocate for ALS awareness and research, determined to produce a difference for others facing the same challenges.

Career Highlights

Dane gained widespread recognition for his portrayal of Dr. Mark Sloan on the long-running medical drama “Grey’s Anatomy.” He also appeared in the HBO series “Euphoria,” and had roles in films such as “X-Men: Last Stand” (2006) and “Burlesque” (2010) [WFMZ].

Final Days and Family

According to a statement released by his representatives, Dane spent his final days surrounded by close friends, his wife, Rebecca Gayheart, and their two daughters, Billie and Georgia, who were the center of his world [WFMZ]. The family has requested privacy during this difficult time.

About ALS

Amyotrophic lateral sclerosis (ALS) is a progressive disease that affects the nerve cells in the brain and spinal cord, leading to a loss of muscle control. The cause of ALS is currently unknown, and there is no cure. Most patients die within three to five years of diagnosis [CBS News], [AP News].

Upcoming Memoir

Eric Dane was working on a memoir titled “Book of Days: A Memoir in Moments,” scheduled for release in 2026 by Maria Shriver’s The Open Field imprint. The memoir was to detail key moments in his life, including his ALS diagnosis and his experiences navigating the illness [AP News].