Lipoic Acid Shows Potential in slowing Gray Matter Loss in Progressive MS
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Rebecca Spain, M.D., M.S.P.H., is lead author on a new randomized controlled clinical trial testing teh over-the-counter supplement lipoic acid in treating progressive forms of multiple sclerosis. (OHSU/Christine Torres Hicks)
The over-the-counter supplement lipoic acid may offer a small benefit in slowing the loss of gray matter in the brains of individuals with progressive forms of multiple sclerosis, according to new research from Oregon Health & Science University and the Portland VA Health Care System.
Study findings
A randomized controlled trial revealed that while lipoic acid didn’t substantially improve walking speed – the primary clinical outcome measured – it showed potential in protecting brain tissue. The research was published today in Neurology, the medical journal of the American Academy of Neurology.
Study Details
The study involved 54 participants diagnosed with primary progressive and secondary progressive multiple sclerosis. Participants in the experimental group received a daily dose of 1,200 milligrams of lipoic acid for two years. Researchers then compared their results to those of 61 participants who received a placebo. Walking speed was the primary outcome measured. Secondary outcomes included brain atrophy, assessed through magnetic resonance imaging (MRI).
Key Results
- lipoic acid did not improve walking speed in participants.
- The study indicated a potential slowing of gray matter loss in the brains of those taking lipoic acid.
- Brain atrophy was measured using MRI scans.
What is Lipoic Acid?
Lipoic acid is a naturally occurring compound found in every cell in the body. It’s known for its antioxidant properties and is available as an over-the-counter dietary supplement. It plays a role in energy production within cells.
Crucial considerations
While these findings are encouraging, it’s crucial to remember that this is one study, and more research is needed.The observed effect on gray matter loss was modest. Individuals with MS should always consult with their healthcare provider before starting any new supplement regimen.
FAQ
Q: Is lipoic acid a cure for MS?
A: No, lipoic acid is not a cure for MS. this study suggests it may have a small beneficial effect on slowing gray matter loss, but it doesn’t address the underlying cause of the disease.
Q: Is lipoic acid safe?
A: Lipoic acid is generally considered safe, but it can interact with certain medications, such as those for diabetes. It’s essential to discuss its use with your doctor.
Q: What type of MS was studied?
A: The study focused on participants with primary progressive and secondary progressive forms of MS.
Key takeaways
- Lipoic acid may slow gray matter loss in progressive MS.
- It did not improve walking speed in this study.
- More research is needed to confirm these findings.
- Consult a healthcare professional before starting any new supplement.
Publication Date: 2025/12/15 22:53:00