Genetic Mutation directly Linked to Increased Risk of Schizophrenia
A team of doctors specializing in genetics and neurology has made a finding that could change how we understand and treat mental health. For the first time, a direct link has been identified between a specific genetic mutation and a notable increase in the risk of developing psychiatric disorders such as schizophrenia.
The findings, published in the journal Molecular psychiatry, suggest that the origin of these pathologies may not be as diffuse as previously thought.
The key to this finding is the GRIN2A gene. Normally, this gene performs a vital function: it regulates communication between neurons through the production of a protein called GluN2A.
Chemobrain affects memory and concentration during or after chemotherapy. Photo:iStock
This protein is essential for the functioning of the NMDA electrical receptor, which facilitates the transmission of nerve signals and allows complex brain processes such as memory, learning, brain development, and language.
Researchers showed that when the GRIN2A gene undergoes a mutation, the activity of the NMDA receptor decreases. This failure in neuronal communication is what increases the risk of suffering from mental illness.
A Paradigm Shift in Psychiatric genetics
Until now, the medical consensus held that mental disorders had a polygenic origin;