2024-01-25 01:13:23
There are new strategies for the treatment of renal clear cell carcinoma – Health News Network – Health Portal{“id”:”492970″,”toptitle”:””,”toptitle_color”:””,”title”:”There are new strategies for the treatment of renal clear cell carcinoma New strategy”,”title_color”:””,”subtitle”:””,”subtitle_color”:””,”crtime”:”2024-01-25 09:13:23″,”condition”:”Source: Health report”,”thumb”: “”}News from this newspaper (Special correspondent Zhou Houliang, correspondent Su Anning)Recently, a new study by the team of Professor Gu Chaohui and Dr. Zhou Lijie from the First Affiliated Hospital of Zhengzhou University revealed that restoring the expression of malonyl-CoA decarboxylase can inhibit the progression of clear cell renal cell carcinoma and improve the sensitivity of sunitinib. This provides a new strategy for the treatment of clear cell renal cell carcinoma. Relevant research papers were published in the international oncology journal Cancer Research.
Renal cancer is one of the common tumors of the urinary system, and renal clear cell carcinoma is the main pathological type, accounting for 70% to 75% of the total. Clear cell renal cell carcinoma stores a large amount of glycogen and lipids in the cytoplasm. The cytoplasm appears transparent in standard pathological staining. Its most important feature is lipid deposition. Abnormal increase in lipid storage promotes the development of clear cell renal cell carcinoma. progress.
Through research, the research team found that the expression level of malonyl-CoA decarboxylase, a key regulator of fatty acid anabolism, is significantly reduced in clear cell renal cell carcinoma, and low expression is associated with poor prognosis of patients. Restoring the expression of malonyl-CoA decarboxylase in clear cell renal cell carcinoma cells inhibits de novo synthesis of fatty acids and promotes the transfer of fatty acids into mitochondria for oxidation. Regulating the intracellular fatty acid content in a way that “increases revenue and reduces expenditure” can completely block the accumulation of lipid droplets in cancer cells, destroy the homeostasis of the endoplasmic reticulum and mitochondria, increase the level of reactive oxygen species, and induce ferroptosis. Furthermore, overexpression of malonyl-CoA decarboxylase slowed tumor growth and restored the sensitivity of drug-resistant cells to sunitinib in vitro and in vivo.
The results of this study indicate that malonyl-CoA decarboxylase-mediated fatty acid anabolism disrupts lipid homeostasis and ultimately inhibits the progression of clear cell renal cell carcinoma. Activating malonyl-CoA decarboxylase-mediated fatty acid anabolism may be a useful Promising strategies for treating clear cell renal cell carcinoma.
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