Vitamin D, Liver Health, and Immunity: Insights from Dr. Olga Radaeva

Recent research presented at the 16th International Congress on Diabetes and Endocrinology in Dubai highlighted the connection between vitamin D levels and the progression of non-alcoholic fatty liver disease (NAFLD). The study, a collaboration between scientists at Ogarev Mordovia State University and the Dedov National Medical Research Center for Endocrinology in Moscow, sheds light on the hormone’s role in immune regulation and overall health. The research was conducted within the framework of the federal program “Priority 2030,” initiated by the Ministry of Science and Higher Education of the Russian Federation. Dr. Olga Radaeva, Head of the Department of Immunology at the Medical Institute of Moscow State University, presented the findings online.

The Collaboration: Bridging University Research and Clinical Endocrinology

The collaboration stemmed from initial research at Mordovia State University focusing on vitamin D and the immune effects of drugs used to treat diabetes and obesity. Dr. Radaeva explained that adipose tissue, often viewed negatively, is an endocrine organ crucial for maintaining immune balance. However, excess adipose tissue can disrupt this balance, leading to inflammation. Her department has spent 25 years studying cytokines – molecules that control immune reactions – and connected with researchers at the Dedov National Medical Research Center for Endocrinology through a conference and the Promomed group of companies [SRMIST]. This connection led to a joint investigation into the immunological aspects of liver disease.

Vitamin D: More Than Just a Vitamin

Dr. Radaeva emphasized that vitamin D is not simply a biologically active substance, but a hormone and a potent immunoregulator. It’s stored in both adipose and muscle tissue, acting as a reserve. Physical activity releases vitamin D back into the bloodstream when needed, contributing to its health benefits. Vitamin D also plays a role in reducing inflammation in liver tissue by “calming” excessive immune activity, and positively impacting the cardiovascular system and autoimmune diseases.

Study Findings: Vitamin D and Non-Alcoholic Fatty Liver Disease

The study examined 161 patients with NAFLD and found a clear correlation between vitamin D levels and immune indicators of inflammation in 86% of cases. However, the research also revealed that some patients with low vitamin D levels did not experience disease progression. This was attributed to genetic variations in vitamin D receptors, suggesting that vitamin D levels aren’t always the decisive factor. Nevertheless, maintaining normal vitamin D levels can offer protective benefits.

Should Everyone Get Their Vitamin D Levels Checked?

Dr. Radaeva suggests that a blood test for vitamin D isn’t necessary for everyone. She recommends that doctors can often prescribe preventative doses of vitamin D without prior testing. She strongly advises choosing a medicinal form of vitamin D over dietary supplements.

Immunity and Diet: Dispelling Myths

Dr. Radaeva addressed the common belief that most people have weakened immunity, calling it a “myth.” She asserts that the immune systems of most individuals are in physiological balance, with lifestyle factors playing a more significant role. She cautioned against the dangerous trend of artificially “strengthening” immunity without medical indication, which can lead to problems. If someone experiences frequent infections, the focus should be on the duration of the illness (up to 10 days is considered normal) rather than the frequency, and addressing factors like sleep, physical activity, and nutrition.

The Role of Diet in Immune Health

Dr. Radaeva emphasized that there is no such thing as “bad food,” but rather an imbalance in dietary diversity. She doesn’t object to occasional indulgences like burgers or cakes, but these shouldn’t become the primary source of calories. A healthy diet should include animal proteins, fiber, and fermented foods.

Active Longevity: Key Factors for a Longer Life

A forum dedicated to active longevity is scheduled to be held in Mordovia in November. Dr. Radaeva highlighted recent medical research identifying key factors influencing life expectancy: adequate sleep (at least 7 hours a day, comparable to the harm of systematic smoking), proper nutrition, and regular physical activity. Her university is currently collaborating with the Talina group of companies, with support from the Head of Mordovia, to develop food products with proven health benefits that may slow the progression of age-related diseases.

About Dr. Olga Radaeva

Dr. Olga Radaeva was born in 1979 in Saransk. She graduated from the Faculty of Medicine of Moscow State University in 2003, specializing in therapy, and completed residency training. She earned her Ph.D. In clinical immunology and allergology in 2009 and her doctoral dissertation in the same field in 2019 at the Moscow Research Institute of Vaccines and Serums. Mechnikova. She currently serves as Head of the Department of Immunology, Microbiology and Virology at Mordovia State University and as the Chief freelance specialist in immunology of the Ministry of Health of the Republic of Moldova. [Loop], [LinkedIn]